Fabrication of pure-drug microneedles for delivery of montelukast sodium

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dc.authoridPrausnitz, Mark/0000-0002-9076-8448
dc.authorscopusid55581214400
dc.authorscopusid7003918121
dc.authorscopusid7006199362
dc.contributor.authorAzizoglu, Erkan
dc.contributor.authorOzer, Ozgen
dc.contributor.authorPrausnitz, Mark R.
dc.date.accessioned2023-01-12T19:51:40Z
dc.date.available2023-01-12T19:51:40Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractDissolving microneedle (MN) patches are usually formulated with a blend of drug and excipients added for mechanical strength and drug stabilization. In this study, we developed MNs made of pure drug to maximize drug loading capacity. MN patches were fabricated for transdermal delivery of montelukast sodium (MS) which is used to treat asthma and allergic rhinitis. We developed three different fabrication methods - solvent casting, melt casting, and solvent washing - and determined that filling molds with MS powder followed by a solvent washing method enabled MS to be loaded selectively to the MNs. Drug localization was confirmed with Raman imaging. MNs were able to penetrate in vitro and ex vivo skin models, and maintained strong mechanical properties during 6 months' storage at 22 degrees C. MS was also stable and compatible with the formulation used for the patch backing layer after 3 months' storage at 40 degrees C. MS delivery efficiency into skin was 55%, which enabled delivery of 3.2 mg MS into porcine skin ex vivo, which is in the range of MS doses in human clinical use. We conclude that the solvent washing method can be used to prepare MNs containing pure drug, such as MS at milligram doses in a similar to 1 -cm(2) MN patch.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey-TUBITAK (2214-A-International Research Fellowship Programme for PhD Students)en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey-TUBITAK (2214-A-International Research Fellowship Programme for PhD Students).en_US
dc.identifier.doi10.1007/s13346-021-01047-9
dc.identifier.endpage458en_US
dc.identifier.issn2190-393X
dc.identifier.issn2190-3948
dc.identifier.issue2en_US
dc.identifier.pmid34480297en_US
dc.identifier.scopus2-s2.0-85114143818en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage444en_US
dc.identifier.urihttps://doi.org/10.1007/s13346-021-01047-9
dc.identifier.urihttps://hdl.handle.net/11454/76309
dc.identifier.volume12en_US
dc.identifier.wosWOS:000692449100002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofDrug Delivery and Translational Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPure-drug formulationen_US
dc.subjectMicroneedle patchen_US
dc.subjectRaman imagingen_US
dc.subjectSkin modelsen_US
dc.subjectMontelukast sodiumen_US
dc.subjectThermal stabilityen_US
dc.subjectPatchesen_US
dc.subjectVaccinationen_US
dc.subjectReleaseen_US
dc.titleFabrication of pure-drug microneedles for delivery of montelukast sodiumen_US
dc.typeArticleen_US

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