Effect of allicin on wound healing: an experimental diabetes model

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dc.contributor.authorToygar, Ismail
dc.contributor.authorTureyen, Aynur
dc.contributor.authorDemir, Derya
dc.contributor.authorCetinkalp, Sevki
dc.date.accessioned2020-12-01T11:59:11Z
dc.date.available2020-12-01T11:59:11Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: the aim of this study was to investigate the effect of allicin on wound healing in an experimental diabetes model. Method: in this randomised controlled study, 50 Wistar albino rats (25 females, 25 males) each weighing 200-300g were used. To develop the diabetes model, 30 rats were induced with 50mg/kg streptozotocin (STZ); 20 rats were not induced in order to compare diabetic and nondiabetic rats. the diabetic rats were divided into three groups, according to dressing material used (allicin, physiological serum and control, where no dressing was used), and the nondiabetic rats were divided into two groups (allicin and control, where no dressing was used). the wound area was calculated and recorded on days 0, 7, 14 and 21. in addition, biopsies were taken from the wound area on days 0, 7, 14 and 21 and used for microscopic examination. Day 0 was used as a reference to calculate wound healing percentage. Results: on days 7 and 14, there were statistically significant differences between groups. Wound surface areas were smaller in the allicin group than in other groups on days 7 and 14. There were no statistically significant differences between the groups on day 21. in addition, it was determined that neutrophil, mononuclear cell, intraepithelial oedema and dermal oedema density were lower and fibroblast, angiogenesis and collagen density were higher in the allicin groups on days 7 and 14. Conclusion: in this study, allicin was found to be potentially effective on wound healing. Future research should be conducted in order to clarify how it affects wound healing.en_US
dc.identifier.doi10.12968/jowc.2020.29.7.388en_US
dc.identifier.endpage392en_US
dc.identifier.issn0969-0700
dc.identifier.issn2062-2916
dc.identifier.issue7en_US
dc.identifier.pmid32654608en_US
dc.identifier.scopus2-s2.0-85087867231en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage388en_US
dc.identifier.urihttps://doi.org/10.12968/jowc.2020.29.7.388
dc.identifier.urihttps://hdl.handle.net/11454/62199
dc.identifier.volume29en_US
dc.identifier.wosWOS:000550773300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMa Healthcare Ltden_US
dc.relation.ispartofJournal of Wound Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectallicinen_US
dc.subjectdiabetic footen_US
dc.subjectin vivoen_US
dc.subjectraten_US
dc.subjectwound healingen_US
dc.titleEffect of allicin on wound healing: an experimental diabetes modelen_US
dc.typeArticleen_US

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