Investigation of Various Virulence Factors and SCCmec Types in the Healthcare-associated and Community-associated Methicillin Resistance Staphylococcus aureus Strains

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dc.contributor.authorKaya, Selçuk
dc.contributor.authorErmertcan, Şafak
dc.contributor.authorÖztürk, İsmail Cengiz
dc.contributor.authorNemli, Salih Atakan
dc.contributor.authorYurtsever, Süreyya Gül
dc.contributor.authorAygül, Abdurrahman
dc.date.accessioned2023-01-12T20:32:29Z
dc.date.available2023-01-12T20:32:29Z
dc.date.issued2020
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: The objective of this study was to investigate some virulence genes and SCCmec types of methicillin-resistant Staphylococcus aureus (MRSA) isolates and to determine their relationship with virulence factors. Methods: A total of 100 MRSA strains, 64 from healthcare-associated and 36 from community-associated infections, were included in the study. The presence of mecA gene was investigated by PCR. SCCmec types and efb, clfB, agrA gene were detected by multiplex PCR and their relationship with virulence factors has been analyzed. Results: All of the isolates contain the mecA gene. At the same time, in 66 strains (66%) agrA gene, in 58 strains (58%) clfB gene, and in 47 strains (47%) efb gene were positive. In terms of SCCmec types, the distribution of these types among the 64 HA-SA strains was 53% similar-to-type-III, 16% type IV, 2% type I and 30% unclassified. The distribution of the types among the 36 CA-SA strains was 19% similar-to-type-III, 25% type IV, 8% type I and 47% unclassified, respectively. When SCCmec types were evaluated according to clinical sample type, similar-to-type-III isolates were found to be dominant in wound samples. Efb (78%), clfB (85%), agrA (88%) were the dominant genes in similar-to-type-III strains, whereas clfB (74%), agrA (100%) were the main genes detected in the type IV strains. Conclusions: It is of clinical and epidemiological importance to know the origin of MRSA strains because this affects the empirical treatment choice.en_US
dc.identifier.doi10.5152/EurJTher.2019.19062
dc.identifier.endpage118en_US
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue2en_US
dc.identifier.startpage113en_US
dc.identifier.trdizinid378271en_US
dc.identifier.urihttps://doi.org/10.5152/EurJTher.2019.19062
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/378271
dc.identifier.urihttps://hdl.handle.net/11454/81145
dc.identifier.volume26en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Therapeuticsen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigation of Various Virulence Factors and SCCmec Types in the Healthcare-associated and Community-associated Methicillin Resistance Staphylococcus aureus Strainsen_US
dc.typeArticleen_US

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