Is D-dimer a predictor of strangulated intestinal hernia?

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dc.contributor.authorIcoz, Gokhan
dc.contributor.authorMakay, Ozer
dc.contributor.authorSozbilen, Murat
dc.contributor.authorGurcu, Baris
dc.contributor.authorCaliskan, Cemil
dc.contributor.authorFirat, Ozgur
dc.contributor.authorKurt, Zahide
dc.contributor.authorErsin, Sinan
dc.date.accessioned2019-10-27T19:40:14Z
dc.date.available2019-10-27T19:40:14Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The goal of this study was to assess the relevance of serum D-dimer measurement as a possible reliable marker for the diagnosis of strangulated intestinal hernia. Methods: Consecutive patients admitted with nontraumatic acute abdominal gastrointestinal disorders were recruited prospectively in a tertiary referral hospital. The study was conducted in 159 patients between August 2002 and April 2004. D-dimer, lactate dehydrogenase, serum amylase, and international normalized ratio (INR) levels were tested in the emergency room prior to surgical intervention. For each patient, 15 variables, including D-dimer, were available for analysis. Results: Thirty-three (20.7%) of the 159 patients had intestinal ischemia, and 28 (85%) of these 33 patients had D-dimer level > 300 ng/ml. Plasma levels of D-dimer in patients with intestinal ischemia were significantly higher than in patients without ischemia (P < 0.05). There were 29 (18.2%) patients in the hernia group with incarceration (n = 22) or strangulation requiring resection (n = 7). D-dimer levels in patients requiring intestinal resection were insignificantly higher than in patients without resection (P > 0.05). Six (85%) of the 7 hernia patients requiring resection had D-dimer levels > 360 ng/ml. The D-dimer variable correlated best with the leukocyte count in patients with hernia requiring resection. Levels of lactate dehydrogenase, serum amylase, and INR did not show any correlation with D-dimer levels. Conclusions: To help predict ischemic events, the increasing use of the D-dimer assay in clinical practice could be extended to patients presenting with intestinal emergencies. An elevated D-dimer level on admission had a high sensitivity for identifying patients with intestinal ischemia, although it had a low specificity. Whether it is predictive or preventive for resection in strangulated intestinal hernia patients still remains a question.en_US
dc.identifier.doi10.1007/s00268-006-0138-xen_US
dc.identifier.endpage2169en_US
dc.identifier.issn0364-2313
dc.identifier.issn1432-2323
dc.identifier.issue12en_US
dc.identifier.pmid17103099en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2165en_US
dc.identifier.urihttps://doi.org/10.1007/s00268-006-0138-x
dc.identifier.urihttps://hdl.handle.net/11454/40243
dc.identifier.volume30en_US
dc.identifier.wosWOS:000242441200013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofWorld Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleIs D-dimer a predictor of strangulated intestinal hernia?en_US
dc.typeArticleen_US

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