Biodistribution of (99m)technetium-labeled creatinine in healthy rats

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dc.contributor.authorYilmaz, O.
dc.contributor.authorLambrecht, F. Yurt
dc.contributor.authorSoylu, A.
dc.contributor.authorDurkan, K.
dc.contributor.authorKavukcu, S.
dc.date.accessioned2019-10-27T19:33:59Z
dc.date.available2019-10-27T19:33:59Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractThe distribution of creatinine, one of the toxic guanidine compounds, in various tissues has not been studied in detail by using radiolabeled creatinine. Our objective was to investigate the biodistribution of creatinine labeled with (99m)technetium (Tc-99m) by the stannous (II) chloride method in healthy male Wistar rats. Quality controls were carried out by radio thin layer chromatography, high- performance liquid chromatography, and paper electrophoresis. The labeling yield was 85 +/- 2% under optimum conditions (pH 7 and 100 mu g stannous chloride). Rats (N = 12) were injected intravenously with Tc-99m-creatinine and their blood and visceral organs were evaluated for Tc-99m-creatinine uptake as percent of the injected dose per gram wet weight of each tissue (% ID/g). The lowest amount of uptake was detected in the brain and testis. When the rate of uptake was evaluated, only the kidney showed increasing rates of uptake of Tc-99m-creatinine throughout the study. Kidneys showed the highest amount of uptake throughout the study (P < 0.001 compared to all other organs), followed by liver, spleen and lung tissue.en_US
dc.identifier.doi10.1590/S0100-879X2006005000111en_US
dc.identifier.endpage812en_US
dc.identifier.issn0100-879X
dc.identifier.issn1678-4510
dc.identifier.issue6en_US
dc.identifier.pmid17581679en_US
dc.identifier.startpage807en_US
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2006005000111
dc.identifier.urihttps://hdl.handle.net/11454/39559
dc.identifier.volume40en_US
dc.identifier.wosWOS:000248409900009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Bras Divulg Cientificaen_US
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbiodistributionen_US
dc.subjectcreatinineen_US
dc.subject(99m)technetiumen_US
dc.subjectTc-99m-creatinineen_US
dc.subjectraten_US
dc.titleBiodistribution of (99m)technetium-labeled creatinine in healthy ratsen_US
dc.typeArticleen_US

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