Effects of tamoxifen on tissue nitrite/nitrate levels and plasma lipid peroxidation in female rats

Basit Öğe Kaydı
dc.contributor.authorGharehbagni M.
dc.contributor.authorSendag F.
dc.contributor.authorAkercan F.
dc.contributor.authorZeybek B.
dc.contributor.authorSezer E.
dc.contributor.authorTerek M.C.
dc.contributor.authorKaradadas N.
dc.date.accessioned2019-10-26T22:34:41Z
dc.date.available2019-10-26T22:34:41Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose of investigation: The effects of tamoxifen on lipid peroxidation and oxidant-antioxidant balance in an animal model were studied. Methods: Twelve female adult rats were divided into two groups and DMSO and tamoxifen dissolved in DMSO were administered. Tissues taken from the brain, liver and ovary of rats were dissected. MDA, nitrite, nitrate levels and plasma LDL oxidation in brain, ovary and liver tissues were measured and compared. Results: Induced LDL MDA levels were significantly lower in the tamoxifen group (p = 0.009). MDA levels in the liver were significantly lower in the tamoxifen group whereas nitrite levels were found significantly higher (p < 0.05). Brain and ovarian tissues demonstrated no significant difference with respect to MDA, nitrite and nitrate levels. Conclusion: Tamoxifen has no negative effects on lipid peroxidation in an animal model.en_US
dc.identifier.endpage114en_US
dc.identifier.issn0390-6663
dc.identifier.issue2en_US
dc.identifier.pmid21077499en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage112en_US
dc.identifier.urihttps://hdl.handle.net/11454/19822
dc.identifier.volume37en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofClinical and Experimental Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMDAen_US
dc.subjectNitrateen_US
dc.subjectNitriteen_US
dc.subjectTamoxifenen_US
dc.titleEffects of tamoxifen on tissue nitrite/nitrate levels and plasma lipid peroxidation in female ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu