Fluctuation of “sperm DNA integrity” in accordance with semen parameters, and it’s relationship with infertility

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dc.contributor.authorDurmaz A.
dc.contributor.authorDikmen N.
dc.contributor.authorGündüz C.
dc.contributor.authorGöker E.N.T.
dc.contributor.authorTavmergen E.
dc.date.accessioned2019-10-27T08:22:25Z
dc.date.available2019-10-27T08:22:25Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractMethods: In this study, DNA damage evaluation was planned in infertile males with the COMET assay, a method which is simple, cheap, sensitive and reliable. For this purpose, the sperm DNA damage of normospermic, oligospermic, asthenospermic and teratospermic cases were investigated and the relationship between sperm parameters (sperm count, motility, morphology) and DNA damage was assessed.Results and conclusion: According to our results we suggest that the factors to blame for sperm DNA damage and semen quality are the same. Also it was found that the infertile males possess substantially more sperm DNA damage than fertile men do. Improving and using the DNA damage evaluation tests seem to improve the results in ART clinics.Purpose: Nowadays sperm analysis is used routinely to assess infertile men, but it’s predictive value is still restricted. For this reason, new markers are needed for diagnosis and guide treatment. A DNA damage evaluation method, which is easily applicable for routine analysis is described in this paper to provide an important support in clinical evaluation. © 2014, Springer Science+Business Media New York.en_US
dc.identifier.doi10.1007/s10815-014-0364-3en_US
dc.identifier.endpage1671en_US
dc.identifier.issn1058-0468
dc.identifier.issue12en_US
dc.identifier.pmid25344267en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1665en_US
dc.identifier.urihttps://doi.org/10.1007/s10815-014-0364-3
dc.identifier.urihttps://hdl.handle.net/11454/26247
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer New York LLCen_US
dc.relation.ispartofJournal of Assisted Reproduction and Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAssisted reproductive technologies (ART)en_US
dc.subjectCOMET assayen_US
dc.subjectDNA damageen_US
dc.subjectMale infertilityen_US
dc.subjectSpermen_US
dc.titleFluctuation of “sperm DNA integrity” in accordance with semen parameters, and it’s relationship with infertilityen_US
dc.typeArticleen_US

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