Electrochemical profiling of natural furanocoumarins: DNA interaction dynamics of oxypeucedanin and prantschimgin

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dc.authoridAlbayrak, Gökay/0000-0002-5729-0796
dc.authoridTOPKAYA, SEDA NUR/0000-0002-7816-3155
dc.authoridKURUL, FATMA/0000-0002-6394-3079
dc.authoridISBILIR, HASAN/0009-0009-9310-5787
dc.contributor.authorKaya, Huseyin Oguzhan
dc.contributor.authorAlbayrak, Gokay
dc.contributor.authorIsbilir, Hasan
dc.contributor.authorKurul, Fatma
dc.contributor.authorBaykan, Sura
dc.contributor.authorHartati, Yeni Wahyuni
dc.contributor.authorTopkaya, Seda Nur
dc.date.accessioned2024-08-31T07:49:45Z
dc.date.available2024-08-31T07:49:45Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and purpose: In this study, we present an electrochemical sensor for the detection of oxypeucedanin (Oxyp) and prantschimgin (Pra), two natural furanocoumarin derivatives. The determination of the effects of these molecules on DNA is important to be potential drug candidates. Our research focused on exploring the electrochemical behaviour of these compounds and their interaction with DNA. Experimental approach: The electrochemical properties of Oxyp and Pra were systematically analyzed by evaluating their oxidation currents. Changes in the oxidation currents and peak potentials of guanine bases were monitored before and after interaction in the solution phase and at the electrode surface. Key results: The limit of detection (LOD) and limit of quantitation (LOQ) for Oxyp were determined to be 1.3 and 4.3 p.g/mL, respectively. For Pra, the LOD and LOQ were found to be 20 and 68 p.g/mL, respectively. Stability studies demonstrated that the Oxyp solution retained its oxidation capacity for over a month, whereas the Pra solution retained its oxidation capacity for nearly 120 min. Our findings suggest that Oxyp interacts with dsDNA, potentially through electrostatic interactions, showing promise as a potential drug candidate targeting DNA. On the other hand, the interaction of Pra with dsDNA requires further exploration to fully understand its mode of action. Conclusion: The electrochemical sensor developed in this study provides a reliable and efficient method for detecting and analysing the interaction of these natural compounds with dsDNA. Our research contributes to advancing the understanding of the interaction between natural furanocoumarins and dsDNA, laying the groundwork for the design and development of novel and effective DNA-targeted drugs.en_US
dc.identifier.doi10.5599/admet.2199
dc.identifier.endpage334en_US
dc.identifier.issn1848-7718
dc.identifier.issue2en_US
dc.identifier.pmid38720926en_US
dc.identifier.scopus2-s2.0-85192913269en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage319en_US
dc.identifier.urihttps://doi.org/10.5599/admet.2199
dc.identifier.urihttps://hdl.handle.net/11454/104990
dc.identifier.volume12en_US
dc.identifier.wosWOS:001181849800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIapc Publishingen_US
dc.relation.ispartofAdmet and Dmpken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectNatural Compoundsen_US
dc.subjectPencil Graphite Electrodeen_US
dc.subjectDrug Candidateen_US
dc.subjectCoumarinsen_US
dc.subjectElectrochemical Detectionen_US
dc.titleElectrochemical profiling of natural furanocoumarins: DNA interaction dynamics of oxypeucedanin and prantschimginen_US
dc.typeArticleen_US

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