Can CD10 be used as a diagnostic marker in thyroid pathology?

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dc.contributor.authorYegen, Guelcin
dc.contributor.authorDemir, Mehmet Akif
dc.contributor.authorErtan, Yesim
dc.contributor.authorNalbant, Olcay Ak
dc.contributor.authorTuncyuerek, Muege
dc.date.accessioned2019-10-27T20:22:11Z
dc.date.available2019-10-27T20:22:11Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractCD10-common acute lymphoblastic leukemia antigen is a membrane-bound zinc metalloproteinase that is expressed by different hematopoietic cell types at unique stages of lymphoid and myeloid differentiation. It was reported to be expressed in various nonlymphoid cells and tissue, as well as in various types of neoplasms. Recently, it has been found to be useful in the differential diagnosis of benign and malignant follicular-patterned lesions of the thyroid. In the present study, we evaluated the staining pattern of CD10 in various thyroid lesions, including 14 benign and 61 malignant cases, as well as in adjacent thyroid tissue. CD10 was negative in normal thyroid tissue, adenomatous nodules, minimally invasive follicular carcinoma, and well-differentiated carcinoma. It was expressed in nine of 14 (64.2%) conventional papillary carcinomas, four of 24 (16.6%) follicular variant of papillary carcinomas, three of six (50%) papillary microcarcinomas, one of nine (11.1%) widely invasive follicular carcinomas, and three of ten (30%) follicular adenomas. In contrast to results of previous studies, CD10 is not useful in the classification of thyroid follicular lesions as benign or malignant, but it shows strong positivity in conventional papillary carcinoma.en_US
dc.identifier.doi10.1007/s00428-008-0698-2en_US
dc.identifier.endpage105en_US
dc.identifier.issn0945-6317
dc.identifier.issn1432-2307
dc.identifier.issue1en_US
dc.identifier.pmid19031085en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://doi.org/10.1007/s00428-008-0698-2
dc.identifier.urihttps://hdl.handle.net/11454/41871
dc.identifier.volume454en_US
dc.identifier.wosWOS:000261792800011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofVirchows Archiven_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThyroiden_US
dc.subjectDifferential diagnosisen_US
dc.subjectCD10-CALLAen_US
dc.titleCan CD10 be used as a diagnostic marker in thyroid pathology?en_US
dc.typeArticleen_US

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