Evaluation of IL-10, MCP-1, IFN gamma, and protectin D1 levels in patients with Hashimoto's thyroiditis

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dc.authoridSUNER, ASLI/0000-0002-6872-9901
dc.authorscopusid56548536700
dc.authorscopusid57982134700
dc.authorscopusid53664427700
dc.authorscopusid23472577300
dc.authorscopusid56638649300
dc.authorscopusid6505834493
dc.authorscopusid12041941200
dc.authorwosidSUNER, ASLI/C-1032-2012
dc.contributor.authorOzisik, Hatice
dc.contributor.authorCekin, Ayse
dc.contributor.authorSuner, Asli
dc.contributor.authorDurmaz, Burak
dc.contributor.authorOzel, Buket
dc.contributor.authorGunel, Nur Selvi
dc.contributor.authorOzgen, Gokhan
dc.date.accessioned2023-01-12T19:51:13Z
dc.date.available2023-01-12T19:51:13Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose Hashimoto's thyroiditis (HT) is one of the most prevalent autoimmune endocrine diseases and caused by the loss of immune tolerance for the thyroid gland. Many pathophysiological mechanisms were speculated about the development of HT. In our study, we aimed to reveal the relationship between HT and IL-10, MCP-1, IFN gamma, and PD1 levels and compare them with control subjects. Methods We collected 37 patients with HT and 25 controls referred to our outpatient clinic. The diagnosis of HT was based on the detection of circulating antibodies to thyroid antigens and decreasing echogenicity on thyroid USG in patients with appropriate clinical characteristics. Serum IL-10, MCP-1, IFN gamma, and PD1 levels were detected using an ELISA KIT (96 T) method according to the manufacturer's instructions. Results All subjects were euthyroid (median TSH level was 1.68 mU/L in HT vs 1.83 mU/L in the controls, p = 0.672). Twenty-three of 37 patients with HT were taking L-thyroxin replacement. Levels of serum IL-10, IFN gamma, and PD1 in patients with HT were higher than the controls, but the differences were not statistically significant (p = 0.393, p = 0.495, and p = 0.052 respectively). The serum levels of MCP-1 in HT patients were statistically different and higher than the controls (p = 0.018). Correlation analysis displayed significant associations between IL-10, MCP-1, IFN gamma, and PD1 levels. Conclusion Our study demonstrated that serum MCP-1 levels in HT patients were significantly increased; on the other hand, significant difference was not found between HT patients and the controls in terms of serum IL-10, IFN gamma, and PD1 levels.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination Unit [TGA-2022-23376]en_US
dc.description.sponsorshipThis project was supported by Ege University Scientific Research Projects Coordination Unit through Project Number: TGA-2022-23376.en_US
dc.identifier.doi10.1007/s11845-022-03231-3
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.pmid36434424en_US
dc.identifier.scopus2-s2.0-85142605340en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1007/s11845-022-03231-3
dc.identifier.urihttps://hdl.handle.net/11454/76238
dc.identifier.wosWOS:000888684300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofIrish Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHashimoto's thyroiditisen_US
dc.subjectInterferon gammaen_US
dc.subjectInterleukin-10en_US
dc.subjectMonocyte chemoattractant protein-1en_US
dc.subjectProtectin D1en_US
dc.titleEvaluation of IL-10, MCP-1, IFN gamma, and protectin D1 levels in patients with Hashimoto's thyroiditisen_US
dc.typeArticleen_US

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