Liquid Biopsy for Promising Non-invasive Diagnostic Biomarkers in Parasitic Infections
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Int Publ Ag
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background Liquid biopsy refers to the sampling and molecular analysis of body fluids such as blood, saliva, and urine in contrast to conventional tissue biopsies. Liquid biopsy approach can offer powerful non-invasive biomarkers (circulating markers) for diagnosis and monitoring treatment response of a variety of diseases, including parasitic infections. Methods In this review, we concentrate on cell-free DNA (cfDNA), microRNA (miRNA), and exosomes in the published literature. Results Considering the high prevalence and severity of parasitic infections worldwide, circulating biomarkers can provide a new insight into the diagnosis and prognosis of parasites in the near future. Moreover, identifying and characterizing parasite- or host-derived circulating markers are important for a better understanding of the pathogenesis of parasite infection and host-parasite relationship at the molecular level. Profiling of biomarkers for parasitic diseases is a promising potential field, though further studies and optimization strategies are required, both in vitro and in vivo. Conclusion In this review, we discuss three approaches in the liquid biopsy including circulating cfDNA, miRNAs, and exosomes for diagnosis and evaluation of parasites and summarize circulating biomarkers in non-invasive samples during parasitic infections.
Açıklama
Anahtar Kelimeler
Liquid biopsy, Cell-free DNA, microRNA, Exosome, Parasite, Cell-Free Dna, Polymerase-Chain-Reaction, Real-Time Pcr, Extracellular Vesicles, Circulating Micrornas, Malaria Detection, Leishmania, Blood, Exosomes, Cancer
Kaynak
Acta Parasitologica
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
67
Sayı
1
