Comparison of quantitative radiomorphometric predictors of healthy and MRONJ-affected bone using panoramic radiography and cone-beam CT

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dc.authoridAslan, Elif/0000-0001-7609-999X
dc.authoridBaksi Sen, Bedriye Guniz/0000-0001-5720-2947
dc.contributor.authorAslan, Elif
dc.contributor.authorOnem, Erinc
dc.contributor.authorMert, Ali
dc.contributor.authorBaksi, B. Guniz
dc.date.accessioned2024-08-31T07:47:49Z
dc.date.available2024-08-31T07:47:49Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives To determine the most distinctive quantitative radiomorphometric parameter(s) for the detection of MRONJ-affected bone changes in panoramic radiography (PR) and cone-beam CT (CBCT). Methods PR and sagittal CBCT slices of 24 MRONJ patients and 22 healthy controls were used for the measurements of mandibular cortical thickness (MCT), fractal dimension (FD), lacunarity, mean gray value (MGV), bone area fraction (BA/TA), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), trabecular number (Tb.N). MCT was measured in the mental foramen region. While FD and lacunarity were measured on mandibular trabecular and cortical regions-of-interest (ROIs), the remaining parameters were measured on trabecular ROIs. The independent samples t-test was used to compare the measurements between the MRONJ and control groups for both imaging modalities (P = .05). Results MCT was the only parameter that differentiated MRONJ-affected bone in both PR and CBCT (P < .05). None of the remaining parameters revealed any difference for MRONJ-affected bone in CBCT (P > .05). FD, lacunarity, MGV, BA/TA, and Tb.Sp could distinguish MRONJ-affected trabecular bone in PR (P < .05). The correspondent ROI for both imaging methods that was reliable for detecting MRONJ-affected bone was the trabecular bone distal to the mental foramen above the inferior alveolar canal (ROI-3). Conclusions MCT is a reliable parameter for the discrimination of MRONJ-affected bone in both PR and CBCT images. PR may be used to detect MRONJ-affected trabecular bone using FD, lacunarity, MGV, BA/TA, and Tb.Sp measurements as well.en_US
dc.description.sponsorshipRobert Frank Award in the Senior/Clinical Research categoryen_US
dc.description.sponsorshipThis study was presented at the CED/NOF IADR Oral Health Research Congress in September 2024 under the title Comparison of 3D Bone Properties of MRONJ Using 2D&3D Images and was awarded with the Robert Frank Award in the Senior/Clinical Research category.en_US
dc.identifier.doi10.1093/dmfr/twae024
dc.identifier.issn0250-832X
dc.identifier.issn1476-542X
dc.identifier.pmid38810135en_US
dc.identifier.urihttps://doi.org/10.1093/dmfr/twae024
dc.identifier.urihttps://hdl.handle.net/11454/104561
dc.identifier.wosWOS:001247140000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofDentomaxillofacial Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectCone-Beam Cten_US
dc.subjectMedication-Related Osteonecrosis Of The Jawsen_US
dc.subjectPanoramic Radiographyen_US
dc.subjectQuantitative Bone Parametersen_US
dc.titleComparison of quantitative radiomorphometric predictors of healthy and MRONJ-affected bone using panoramic radiography and cone-beam CTen_US
dc.typeArticleen_US

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