In vitro evaluation of estrogenic, antiestrogenic and antitumor effects of amentoflavone

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dc.contributor.authorAliyev, A. T.
dc.contributor.authorOzcan-Sezer, S.
dc.contributor.authorAkdemir, A.
dc.contributor.authorGurer-Orhan, H.
dc.date.accessioned2021-05-03T20:27:33Z
dc.date.available2021-05-03T20:27:33Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractApigenin, a flavonoid, is reported to act as an estrogen receptor (ER) agonist and inhibit aromatase enzyme. However, amentoflavone, a biflavonoid bearing two apigenin molecules, has not been evaluated for its endocrine modulatory effects. Besides, it is highly consumed by young people to build muscles, enhance mood and lose weight. in the present study, apigenin was used as a reference molecule and ER mediated as well as ER-independent estrogenic/antiestrogenic activity of amentoflavone was investigated. Antitumor activity of amentoflavone was also investigated in both ER positive (MCF-7 BUS) and triple-negative (MDA-MB-231) breast cancer cells and its cytotoxicity was evaluated in human breast epithelial cells (MCF-10A). Our data confirmed ER agonist, aromatase inhibitory and cytotoxic effects of apigenin in breast cancer cells, where no ER mediated estrogenic effect and physiologically irrelevant, slight, aromatase inhibition was found for amentoflavone. Although selective cytotoxicity of amentoflavone was found in MCF-7 BUS cells, it does not seem to be an alternative to the present cytotoxic drugs. Therefore, neither an adverse effect, mediated by an estrogenic/antiestrogenic effect of amentoflavone nor a therapeutical benefit would be expected from amentoflavone. Further studies could be performed to investigate its in vivo effects.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112S375]; Ege University Scientific Research ProjectEge University [13ECZ008]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Scientific and Technological Research Council of Turkey under Grant No. 112S375 and Ege University Scientific Research Project under Grant No. 13ECZ008.en_US
dc.identifier.doi10.1177/0960327121999454en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.pmid33678040en_US
dc.identifier.urihttps://doi.org/10.1177/0960327121999454
dc.identifier.urihttps://hdl.handle.net/11454/69561
dc.identifier.wosWOS:000636499000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApigeninen_US
dc.subjectamentoflavoneen_US
dc.subjectaromataseen_US
dc.subjectestrogenicen_US
dc.subjectantiestrogenicen_US
dc.subjectcytotoxicityen_US
dc.titleIn vitro evaluation of estrogenic, antiestrogenic and antitumor effects of amentoflavoneen_US
dc.typeArticleen_US

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