The Association of Macrophage Activation-Like Syndrome with Mortality in Elderly Patients with Sepsis

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dc.authoridkilincer bozgül, sukriye miray/0000-0002-3995-5096
dc.authoridAk, Gunes/0000-0001-6780-1812
dc.authoridAydin, Ozgur/0000-0002-8907-2195
dc.authoridKURTULMUS, ILKCE AKGUN/0000-0002-2661-8525
dc.authoridACAR, CANER/0000-0002-9782-6807
dc.contributor.authorBozgul, Sukriye Miray Kilincer
dc.contributor.authorAcar, Caner
dc.contributor.authorKurtulmus, Ilkce Akgun
dc.contributor.authorAydin, Ozgur
dc.contributor.authorKoca, Didem
dc.contributor.authorAk, Gunes
dc.contributor.authorCilli, Fatma Feriha
dc.date.accessioned2024-08-31T07:46:35Z
dc.date.available2024-08-31T07:46:35Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Among the geriatric population, when compared to younger individuals, mortality is high. Macrophage activation-like syndrome (MALS) has been reported to be an independent immunological entity associated with mortality among sepsis patients in adults which represents the increased inflammation state. This study aimed to investigate the frequency of MALS in elderly sepsis patients and its association with intensive care unit (ICU) mortality. Materials and Methods: This retrospective study included patients aged 65 years or older with sepsis between January 2013 and January 2022 in the ICU of the Internal Medicine Department of Ege University Hospital. MALS was diagnosed with a hemophagocytic syndrome score (H-score) of =151 and/or co-presence of hepatobiliary dysfunction (HBD) and disseminated intravascular coagulation (DIC). Clinical, demographic, and laboratory results were retrieved from the medical records. Factors affecting ICU mortality were investigated with binary logistic regression analysis. Results: In our study of 194 patients, mortality was 46.4% and MALS frequency was 23.7%. Among non-survivors, MALS frequency was significantly higher than survivors; 32.2% and 16.3%, p= 0.010. The median H-score was 117 in non-survivors and 78.5 in survivors, p= 0.002. ICU mortality of elderly sepsis patients increased by approximately 25 times when MALS was present. Age was not identified as a risk factor for ICU mortality. Conclusion: Among elderly sepsis patients, the frequency of MALS was found to be remarkably high in our single-center study. MALS may be one of the reasons for increased mortality in elderly sepsis patients.en_US
dc.identifier.doi10.5578/flora.20239609
dc.identifier.endpage667en_US
dc.identifier.issn1300-932X
dc.identifier.issn2602-2842
dc.identifier.issue4en_US
dc.identifier.startpage658en_US
dc.identifier.trdizinid1213553en_US
dc.identifier.urihttps://doi.org/10.5578/flora.20239609
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1213553
dc.identifier.urihttps://hdl.handle.net/11454/104122
dc.identifier.volume28en_US
dc.identifier.wosWOS:001167102900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherBilimsel Tip Yayinevien_US
dc.relation.ispartofFlora Infeksiyon Hastaliklari ve Klinik Mikrobiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectSepsisen_US
dc.subjectMacrophagesen_US
dc.subjectMortalityen_US
dc.subjectElderlyen_US
dc.subjectCritical Careen_US
dc.titleThe Association of Macrophage Activation-Like Syndrome with Mortality in Elderly Patients with Sepsisen_US
dc.typeArticleen_US

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