Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication

Basit Öğe Kaydı
dc.contributor.authorAghamohammadi, Asghar
dc.contributor.authorAbolhassani, Hassan
dc.contributor.authorKutukculer, Necil
dc.contributor.authorWassilak, Steve G.
dc.contributor.authorPallansch, Mark A.
dc.contributor.authorKluglein, Samantha
dc.contributor.authorQuinn, Jessica
dc.contributor.authorSutter, Roland W.
dc.contributor.authorWang, Xiaochuan
dc.contributor.authorSanal, Ozden
dc.contributor.authorLatysheva, Tatiana
dc.contributor.authorIkinciogullari, Aydan
dc.contributor.authorBernatowska, Ewa
dc.contributor.authorTuzankina, Irina A.
dc.contributor.authorCosta-Carvalho, Beatriz T.
dc.contributor.authorLuis Franco, Jose
dc.contributor.authorSomech, Raz
dc.contributor.authorKarakoc-Aydiner, Elif
dc.contributor.authorSingh, Surjit
dc.contributor.authorBezrodnik, Liliana
dc.contributor.authorEspinosa-Rosales, Francisco J.
dc.contributor.authorShcherbina, Anna
dc.contributor.authorLau, Yu-Lung
dc.contributor.authorNonoyama, Shigeaki
dc.contributor.authorModell, Fred
dc.contributor.authorModell, Vicki
dc.contributor.authorBarbouche, Mohamed-Ridha
dc.contributor.authorMcKinlay, Mark A.
dc.date.accessioned2019-10-27T11:07:26Z
dc.date.available2019-10-27T11:07:26Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractImmunodeficiency-associated vaccine-derived polioviruses (iVDPVs) have been isolated from primary immunodeficiency (PID) patients exposed to oral poliovirus vaccine (OPV). Patients may excrete poliovirus strains for months or years; the excreted viruses are frequently highly divergent from the parental OPV and have been shown to be as neurovirulent as wild virus. Thus, these patients represent a potential reservoir for transmission of neurovirulent polioviruses in the post-eradication era. In support of WHO recommendations to better estimate the prevalence of poliovirus excreters among PIDs and characterize genetic evolution of these strains, 635 patients including 570 with primary antibody deficiencies and 65 combined immunodeficiencies were studied from 13 OPV-using countries. Two stool samples were collected over 4 days, tested for enterovirus, and the poliovirus positive samples were sequenced. Thirteen patients (2%) excreted polioviruses, most for less than 2 months following identification of infection. Five (0.8%) were classified as iVDPVs (only in combined immunodeficiencies and mostly poliovirus serotype 2). Non-polio enteroviruses were detected in 30 patients (4.7%). Patients with combined immunodeficiencies had increased risk of delayed poliovirus clearance compared to primary antibody deficiencies. Usually, iVDPV was detected in subjects with combined immunodeficiencies in a short period of time after OPV exposure, most for less than 6 months. Surveillance for poliovirus excretion among PID patients should be reinforced until polio eradication is certified and the use of OPV is stopped. Survival rates among PID patients are improving in lower and middle income countries, and iVDPV excreters are identified more frequently. Antivirals or enhanced immunotherapies presently in development represent the only potential means to manage the treatment of prolonged excreters and the risk they present to the polio endgame.en_US
dc.description.sponsorshipBill & Melinda Gates FoundationGates Foundationen_US
dc.description.sponsorshipThis work was funded by a grant from the Bill & Melinda Gates Foundation.en_US
dc.identifier.doi10.3389/fimmu.2017.00685en_US
dc.identifier.issn1664-3224
dc.identifier.pmid28952612en_US
dc.identifier.urihttps://doi.org/10.3389/fimmu.2017.00685
dc.identifier.urihttps://hdl.handle.net/11454/32027
dc.identifier.volume8en_US
dc.identifier.wosWOS:000403113800002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers in Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpoliovirus eradicationen_US
dc.subjectimmunodeficiency-associated vaccine-derived poliovirusesen_US
dc.subjectoral poliovirus vaccineen_US
dc.subjecthumoral immunodeficiencyen_US
dc.subjectcombined immunodeficiencyen_US
dc.subjectprimary immunodeficiencyen_US
dc.titlePatients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradicationen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu