Angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AT1R) gene polymorphisms in generalized aggressive periodontitis

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dc.contributor.authorGurkan, Ali
dc.contributor.authorEmingil, Guelnur
dc.contributor.authorSaygan, Buket Han
dc.contributor.authorAtilla, Guel
dc.contributor.authorKose, Timur
dc.contributor.authorBaylas, Haluk
dc.contributor.authorBerdeli, Afig
dc.date.accessioned2019-10-27T20:52:30Z
dc.date.available2019-10-27T20:52:30Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Host response to periodontopathic microorganisms can be modulated by genetic factors. Accumulated evidence highlighted the role of renin-angiotensin system (RAS) in inflammatory response thus potential implication of this molecular system in the pathogenesis of periodontitis can be suggested. The present study investigated common genetic variants of molecules within the RAS family namely angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin 11 type 1 receptor (AT1R) in relation to generalized aggressive periodontitis (G-AgP). Methods: DNA was obtained from peripheral blood of 103 G-AgP patients and 100 periodontally healthy subjects. ACE I/D, AGT M235T and AT1R A1166C polymorphisms were genotyped by polymerase chain reaction and restriction fragment length polymorphism method. Chi-square, ANOVA and logistic regression were used in statistical analyses. Results: Both ACE I/D and ATIR polymorphisms were similar in G-AgP and healthy groups (p>0.05). G-AgP subjects exhibited decreased ACT TT genotype and T allele frequency as compared to healthy subjects (p<0.05). The same trend was also observed in the nonsmoker subgroup regarding investigated RAS polymorphisms. Conclusions: Present findings suggest that AGT M235T TT genotype and T allele might be associated with decreased risk for G-AgP in Turkish population. (C) 2009 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.archoralbio.2008.12.005en_US
dc.identifier.endpage344en_US
dc.identifier.issn0003-9969
dc.identifier.issue4en_US
dc.identifier.pmid19162259en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2008.12.005
dc.identifier.urihttps://hdl.handle.net/11454/43238
dc.identifier.volume54en_US
dc.identifier.wosWOS:000264945500006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeriodontitisen_US
dc.subjectACEen_US
dc.subjectAGTen_US
dc.subjectAT1Ren_US
dc.subjectPolymorphismen_US
dc.titleAngiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AT1R) gene polymorphisms in generalized aggressive periodontitisen_US
dc.typeArticleen_US

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