Folic-Acid-Modified Conducting Polymer: Electrochemical Detection of the Cell Attachment

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dc.contributor.authorAzak, Hacer
dc.contributor.authorBarlas, Firat Baris
dc.contributor.authorYildiz, Huseyin Bekir
dc.contributor.authorGulec, Kadri
dc.contributor.authorDemir, Bilal
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorTimur, Suna
dc.date.accessioned2019-10-27T23:10:34Z
dc.date.available2019-10-27T23:10:34Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractHere, postfunctionalization and bioapplication of a pi-conjugated polymer named 4-[4H-dithieno(3,2-b:2',3'-d)pyrrol-4-yl]aniline (DTP-aryl-NH2) are reported, which is successfully synthesized via electropolymerization onto the glassy carbon electrode. Folic acid (FA) is used to modify the amino functional polymer via N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide chemistry for the further steps. The selective adhesion of folate receptor positive cells on the surface is followed by the electrochemical methods. Cyclic voltammetry and electrochemical impedance spectroscopy have been used to characterize stepwise modification of the electroactive surface. After optimization studies such as scan rate during the polymer deposition, FA amount for the efficient surface targeting, incubation time with the cells etc., analytical characterization is carried out. The surface morphologies at each step are imaged by using fluorescence microscopy.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (Tubitak)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z918]; Foundation of Ege UniversityEge University [12-TIP-104, 14-FEN-023]; Turkish Academy of Sciences-Outstanding Young Scientists Award Program (TUBA-GEBIP)Turkish Academy of Sciencesen_US
dc.description.sponsorshipAuthors thank to Scientific and Technological Research Council of Turkey (Tubitak; Project No: 113Z918) and Foundation of Ege University (project numbers 12-TIP-104 and 14-FEN-023). Dr. D.O. Demirkol thanks to The Turkish Academy of Sciences-Outstanding Young Scientists Award Program-2015 (TUBA-GEBIP).en_US
dc.identifier.doi10.1002/mabi.201500274en_US
dc.identifier.endpage552en_US
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.issue4en_US
dc.identifier.pmid26671168en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.1002/mabi.201500274
dc.identifier.urihttps://hdl.handle.net/11454/52920
dc.identifier.volume16en_US
dc.identifier.wosWOS:000374262100007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofMacromolecular Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcell adhesionen_US
dc.subjectcell detectionen_US
dc.subjectconducting polymeren_US
dc.subjectsurface modificationen_US
dc.titleFolic-Acid-Modified Conducting Polymer: Electrochemical Detection of the Cell Attachmenten_US
dc.typeArticleen_US

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