Factors affecting survival in liver metastasis of colorectal cancer
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Colorectal cancer is among the most common malignancies and liver metastasis is developed in 50% of the patients. Hepatic resection is the most effective treatment in liver metastasis of colorectal cancer. The present study aimed to determine the factors that affect survival in patients who underwent hepatic resection in liver metastasis of colorectal cancer. Materials and Methods: The data on patients who underwent hepatic resection due to liver metastasis of colorectal cancer in Ege University, Faculty of Medicine, General Surgery Department were retrospectively analyzed. Survival data were collected with the review of patient follow-up files. The effects of the factors pertaining to the patients on survival were determined. Results: The mean age of the 62 participating patients was 58.08 ± 10.92 years. Total survival rate was 50.4 months (CI: 41.2-59.7). The factors that statistically significantly reduced the survival rate were determined as follows: Patient age> 65 (<65 years: 56.4 ± 5.5 months / ?65 years: 29.3 ± 4.8 months, p = 0.007), presence of more than four lymph node metastases in the primary tumor (N0: 56.1 ± 7.9 months / N1: 56.5 ± 6.5 months / N2: 18.0 ± 3.0, p = 0.001), presence of bilobular liver metastasis (Uni-lobular: 53.4 ± 5.0 months / bilobular: 24.0 ± 4.4 months, p = 0.026), an d liver resection margin closer than 2 mm (<2 mm: 28.4 ± 7.7 months / 2-9 mm: 61.1 ± 7 , 6 months, ?10mm: 46.3 ± 5.9 months, p = 0.003). No statistically significant differences were determined in survival based on gender, location of the primary tumor, the invasion depth of the primary tumor, the time between colorectal and liver surgery, the carcinoembryonic antigen level, the metastasis diameter, the number of metastases and the extent of surgical resection. Conclusion: In patients who underwent surgical resection for liver metastasis of colorectal cancer, age older than sixty-five years, the presence of more than four lymph nodes in the colon resection material, bilobular liver metastasis, and a surgical margin closer than 2 mm were poor prognostic factors.
Açıklama
Anahtar Kelimeler
Kaynak
Ege Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
60
Sayı
4
