The Severity of Coronary Arterial Stenosis in Patients With Acute ST-Elevated Myocardial Infarction: A Thrombolytic Therapy Study

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dc.contributor.authorKilic, Salih
dc.contributor.authorKocabas, Umut
dc.contributor.authorCan, Levent Hurkan
dc.contributor.authorYavuzgil, Oguz
dc.contributor.authorZoghi, Mehdi
dc.date.accessioned2019-10-27T10:42:57Z
dc.date.available2019-10-27T10:42:57Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: It is widely believed that ST-elevated myocardial infarction (STEMI) generally occurs at the site of mild to moderate coronary stenosis. The aim of this study was to determine the degree of stenosis of infarct-related artery (IRA) in STEMI patients who underwent coronary angiography (CAG) after successful reperfusion with thrombolytic therapy (TT). Methods: A total of 463 consecutive patients between January 2008 and December 2013 with acute STEMI treated with TT were evaluated retrospectively. The patients in whom reperfusion failed (n = 120), death occurred before CAG (n = 12), IRA cannot be determined (n = 10), and CAG was not performed in index hospitalization (n = 54) were excluded from the study. To determine the severity of stenosis of IRA, two experienced cardiologists who were unaware of each other used quantitative CAG analysis. Significant stenosis was defined as a >= 50% stenosis in the coronary artery lumen. A total of 267 patients who were successfully reperfused with TT and in whom CAG was performed during hospitalization with median 8 (1 - 17) days after myocardial infarction were included in the study. Results: The mean age of patients was 55.7 +/- 10.8 years (85.5% male). Most of the patients had a significant stenosis in IRA (>= 50%, n = 236, group 1) after successful TT; whereas only 11.6% had stenosis < 50% (n = 31, group 2). In addition, majority of the patients had >= 70.4% (n = 188, 70.4%) stenosis in IRA. Average of stenosis in IRA was 74 +/- 16%. Conclusions: In contrast to the general opinion, we detected that majority of STEMI patients had a significant stenosis in IRA.en_US
dc.identifier.doi10.14740/cr639wen_US
dc.identifier.endpage16en_US
dc.identifier.issn1923-2829
dc.identifier.issn1923-2837
dc.identifier.issue1en_US
dc.identifier.pmid29479380en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.14740/cr639w
dc.identifier.urihttps://hdl.handle.net/11454/30703
dc.identifier.volume9en_US
dc.identifier.wosWOS:000428722400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElmer Press Incen_US
dc.relation.ispartofCardiology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSeverity coronary arteryen_US
dc.subjectSTEMIen_US
dc.subjectThrombolytic therapyen_US
dc.titleThe Severity of Coronary Arterial Stenosis in Patients With Acute ST-Elevated Myocardial Infarction: A Thrombolytic Therapy Studyen_US
dc.typeArticleen_US

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