Kemik iliği transplantasyonu yapılan pediyatrik olgularda mukokutanöz bulgular
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Kemik iliği transplantasyonu (KİT), pediyatrik hastalarda birçok malign ve malign olmayan hastalıkta kullanılmaktadır. Transplantasyon yapılan hastalarda gözlenen deri belirtileri, genellikle altta yatan primer hastalığa ya da uygulanan yoğun kemoterapi ve radyoterapi protokollerine bağlı olarak ortaya çıkmaktadır. Bu çalışmada, KİT yapılan pediyatrik olgularda mukokutanöz lezyonların tanımlanması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya 2010-2011 yılları arasında KİT yapılması planlanan toplam 44 hasta dahil edilmiştir. Olguların ilk dermatolojik muayeneleri yapıldıktan sonra ilk ay içerisinde her hafta, takip eden 5 aylık süreçte ayda bir ve son 1,5 yılda ise her 3 ayda bir dermatolojik muayeneleri tekrarlanmıştır.Bulgular: Kırk bir olgu çalışmayı tamamladı. Toplam 41 olgunun yaş ortalaması 9,24 (minimum=1 yaş, maksimum=17 yaş); hastaların 26'sı (%64) erkek, 15'i (%36) kadındır. Görülme sıklığı oranlarına göre dermatolojik belirtiler mukozit (%75,6), kseroderma (%70,7), alopesi (%46,3), aftöz stomatit (%22), kutanöz hiperpigmentasyon (%22), tırnak bozuklukları (%24,3), enflamatuvar deri hastalıkları (%24,2), enfeksiyöz hastalıklar (%15,5), graft versus host hastalığı (%17,1) ve makülopapüler döküntü (%4,8) şeklinde sıralanmıştır. Sonuç: KİT hastalarında dermatolojik hastalıklar sıklıkla görülebilmektedir. Dermatolojik belirtilerin yakın takibi bu hasta grubunda tedavinin komplikasyonlarını azaltmada önemlidir
Background and Design: Bone marrow transplantation (BMT) is performed for many malign and non-malign diseases in pediatric patients. Cutaneous signs in transplant patients are usually encountered in the presence of underlying primary diseases or due to the intense conditioning regimens that include chemotherapy and radiotherapy protocols. In this study, it is aimed to define mucocutaneous changes in pediatric patients with BMT.Materials and Methods: A total of 44 patients, in whom BMT was planned between 2010 and 2011, were included in the study. Dermatological examinations were performed at the beginning of the study and were repeated once a week in the first month, once a month in the following 5 months; and once in every 3 months in the last 1.5 years of follow-up.Results: Forty-one patients were completed the study. The mean age of 41 patients was 9.24 years (range: 1-17 years). Of the subjects, 26 (64%) were male and 15 (36%) were female. Dermatological signs, in order of frequency, were mucositis (75.6%), xeroderma (70.7%), alopecia (46.3%), nail disorders (24.3%), inflammatory skin diseases (24.2%), aphthous stomatitis (22%), cutaneous hyperpigmentation (22%), graft versus host diseases (17.1%), infectious diseases (15.5%), and maculopapular rash (4.8%).Conclusion: Dermatological diseases can be frequently observed in BMT patients. Close monitoring of dermatological signs is important to minimize the complications of the treatment in this patient group
Background and Design: Bone marrow transplantation (BMT) is performed for many malign and non-malign diseases in pediatric patients. Cutaneous signs in transplant patients are usually encountered in the presence of underlying primary diseases or due to the intense conditioning regimens that include chemotherapy and radiotherapy protocols. In this study, it is aimed to define mucocutaneous changes in pediatric patients with BMT.Materials and Methods: A total of 44 patients, in whom BMT was planned between 2010 and 2011, were included in the study. Dermatological examinations were performed at the beginning of the study and were repeated once a week in the first month, once a month in the following 5 months; and once in every 3 months in the last 1.5 years of follow-up.Results: Forty-one patients were completed the study. The mean age of 41 patients was 9.24 years (range: 1-17 years). Of the subjects, 26 (64%) were male and 15 (36%) were female. Dermatological signs, in order of frequency, were mucositis (75.6%), xeroderma (70.7%), alopecia (46.3%), nail disorders (24.3%), inflammatory skin diseases (24.2%), aphthous stomatitis (22%), cutaneous hyperpigmentation (22%), graft versus host diseases (17.1%), infectious diseases (15.5%), and maculopapular rash (4.8%).Conclusion: Dermatological diseases can be frequently observed in BMT patients. Close monitoring of dermatological signs is important to minimize the complications of the treatment in this patient group
Açıklama
Anahtar Kelimeler
Dermatoloji
Kaynak
Türkderm-Deri Hastalıkları ve Frengi Arşivi
WoS Q Değeri
Scopus Q Değeri
Cilt
51
Sayı
1
