Changes in the dermoscopic appearance of melanocytic naevi after photochemotherapy or narrow-band ultraviolet B phototherapy

Basit Öğe Kaydı
dc.contributor.authorKaraarslan, I. Kilinc
dc.contributor.authorTeban, L.
dc.contributor.authorDawid, M.
dc.contributor.authorTanew, A.
dc.contributor.authorKittler, H.
dc.date.accessioned2019-10-27T19:35:19Z
dc.date.available2019-10-27T19:35:19Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Although phototherapeutic modalities are commonly used for the treatment of skin diseases, the effects of therapeutic ultraviolet (UV) irradiation on the dermoscopic appearance of melanocytic naevi are unknown. Objectives We aimed to analyse the effects of photochemotherapy (psoralen plus ultraviolet A, PUVA) and narrow-band ultraviolet B phototherapy (NB-UVB) on the dermoscopic appearance of naevi. Patients and methods We monitored 187 melanocytic naevi of 38 patients receiving NB-UVB or PUVA treatment for miscellaneous skin diseases. Dermoscopic images of naevi were taken before, shortly after, and after a median of 31 weeks after the UV therapy. A random selection of naevi was covered during UV treatment, the others remained uncovered. Baseline and follow-up images of naevi were viewed side by side on a computer screen to compare size, pigmentation, and dermoscopic structure of naevi. Results Twenty-one patients received NB-UVB treatment, and 17 patients received PUVA treatment. Of 187 naevi, 70 (37%) were covered and 117 (63%) were uncovered during UV treatment. When NB-UVB- and PUVA-treated patients were analysed together, an increase in size of uncovered lesions was seen in both treatment groups. Pigmentation appeared darker at the end of UV treatment in 67.5% (n = 79) of uncovered naevi compared with 41.4% (n = 29) of covered naevi (P < 0.001). In patients receiving NB-UVB therapy, a significant increase in the number of dots or globules in 20.3% (n = 14) of uncovered naevi compared with only 5.0% (n = 2) of covered naevi (P = 0.03) was found. This effect was not observed after PUVA therapy. With the exception of four naevi with continuous enlargement and seven naevi with a persisting increase in dots and globules, the observed changes were reversible. All naevi with persistent changes belonged to the NB-UVB group. Conclusion In general, PUVA and NB-UVB therapy cause reversible dermoscopic changes in melanocytic naevi. Increase in dots and globules is more frequent with NB-UVB.en_US
dc.identifier.doi10.1111/j.1468-3083.2006.02020.xen_US
dc.identifier.endpage531en_US
dc.identifier.issn0926-9959
dc.identifier.issn1468-3083
dc.identifier.issue4en_US
dc.identifier.pmid17373982en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage526en_US
dc.identifier.urihttps://doi.org/10.1111/j.1468-3083.2006.02020.x
dc.identifier.urihttps://hdl.handle.net/11454/39725
dc.identifier.volume21en_US
dc.identifier.wosWOS:000244968900015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of the European Academy of Dermatology and Venereologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdermoscopyen_US
dc.subjectmelanocytic naevien_US
dc.subjectnarrow-band UVB phototherapyen_US
dc.subjectphotochemotherapyen_US
dc.titleChanges in the dermoscopic appearance of melanocytic naevi after photochemotherapy or narrow-band ultraviolet B phototherapyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu