The association between genetic polymorphisms in matrix metalloproteinases and caries experience

Basit Öğe Kaydı
dc.contributor.authorDindaroglu, Funda Cagirir
dc.contributor.authorEronat, Nesrin
dc.contributor.authorDurmaz, Asude
dc.contributor.authorCogulu, Dilsah
dc.contributor.authorDurmaz, Burak
dc.contributor.authorCogulu, Ozgur
dc.date.accessioned2021-05-03T20:27:43Z
dc.date.available2021-05-03T20:27:43Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives The variation in the caries susceptibility while environmental factors are similar indicates that the effect of individual factors such as genetics on caries process and tooth development should be revealed. The aim of this study was to evaluate the association between genetic polymorphisms in MMP13 (rs2252070) and MMP20 (rs1784418) with caries experience. Materials and methods A cross-sectional study was conducted on 200 subjects aged 6 to 14 years. Demographic data, data on oral health habits were obtained through the statements of guardian of the individuals, caries data was collected by clinical examination. Unstimulated whole saliva was collected to extract the genomic DNA. Genotyping of the selected polymorphisms was carried out by real-time PCR. Allele and genotype frequencies were compared between different subgroups considering caries experience. Data were analyzed using SPSS 16.0 by chi-square test and logistic regression analysis. Results Allele distribution of MMP13 was different between caries-affected and caries-free subjects. MMP13 A allele increased the caries risk (p=0.005, OR=1.84, 95% CI 1.20-2.82). Allele and genotype distribution of the polymorphism in MMP20 were not associated with caries experience (p>0.05). Conclusions It is concluded that the genetic variation in MMP13 was associated with the caries experience in selected subjects in Turkey.en_US
dc.description.sponsorshipEge University Scientific Research Projects CoordinationEge University [610120140006]en_US
dc.description.sponsorshipThe authors received no specific funding for this work. This study was supported by Ege University Scientific Research Projects Coordination (Grant number: 610120140006).en_US
dc.identifier.doi10.1007/s00784-021-03848-1en_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.pmid33638713en_US
dc.identifier.scopus2-s2.0-85101909228en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00784-021-03848-1
dc.identifier.urihttps://hdl.handle.net/11454/69628
dc.identifier.wosWOS:000622675200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDental cariesen_US
dc.subjectMatrix metalloproteinaseen_US
dc.subjectGenetic polymorphismen_US
dc.subjectGenetic susceptibilityen_US
dc.titleThe association between genetic polymorphisms in matrix metalloproteinases and caries experienceen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu