"Biomimetic-electrochemical-sensory-platform" for biomolecule free cocaine testing

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dc.contributor.authorSengel, Tulay Yilmaz
dc.contributor.authorGuler, Emine
dc.contributor.authorArslan, Mustafa
dc.contributor.authorGumus, Z. Pinar
dc.contributor.authorSanli, Serdar
dc.contributor.authorAldemir, Ebru
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2021-05-03T20:41:35Z
dc.date.available2021-05-03T20:41:35Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.descriptionSanli, Serdar/0000-0002-9048-287X; aldemir, ebru/0000-0002-3808-1956; Guler Celik, Emine/0000-0003-2381-9775; ARSLAN, Mustafa/0000-0003-3994-1900; Odaci Demirkol, Dilek/0000-0002-7954-1381en_US
dc.description.abstractA biomimetic cocaine sensor was fabricated by using poly(p-phenylene) (PPP) with cyclodextrin (CD) units in the backbone and poly(ethylene glycol) (PEG) side chains (PPP-CD-g-PEG). The sensory platform was constructed by one step surface modification of glassy carbon electrode with PPP-CD-g-PEG by drop coating. The electrochemical measurements are based on the formation of CD-cocaine inclusion complex on the surface resulting in a significant decrease in electron transfer capacity of the selected redox probe. The changes in the surface features due to cocaine binding were explored via electrochemical techniques such as differential pulse voltammetry, cyclic voltammetry and electrochemical impedance spectrometry. The sensor exhibited linearity in the range of 25-200 nM cocaine, LOD was calculated as 28.62 nM (n = 5) according to 3Sb/m formula. Finally, the sensory platform was successfully applied for the cocaine analysis in synthetic urine samples and correlated with the chromatographic method.en_US
dc.description.sponsorshipRepublic of Turkey, Ministry of DevelopmentTurkiye Cumhuriyeti Kalkinma Bakanligi [2016K121190]; Ege University Research Fund through BAP projects [16-FEN-004, 14-FEN-019]; Istanbul Technical University Research Funden_US
dc.description.sponsorshipThis work was funded by Republic of Turkey, Ministry of Development (Project Grant No: 2016K121190). This work was also partially supported by Ege University Research Fund through BAP projects (Project No: 16-FEN-004 and Project No: 14-FEN-019) and Istanbul Technical University Research Fund. Likrom Company was acknowledged for their support to the chromatographic analyses.en_US
dc.identifier.doi10.1016/j.msec.2018.04.043en_US
dc.identifier.endpage218en_US
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid29853084en_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.1016/j.msec.2018.04.043
dc.identifier.urihttps://hdl.handle.net/11454/70623
dc.identifier.volume90en_US
dc.identifier.wosWOS:000435619600022en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclodextrinen_US
dc.subjectBiomimetic materialen_US
dc.subjectElectrochemical sensoren_US
dc.subjectCocaine testingen_US
dc.title"Biomimetic-electrochemical-sensory-platform" for biomolecule free cocaine testingen_US
dc.typeArticleen_US

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