Fullerene-C60-MWCNT composite film based ultrasensitive electrochemical sensing platform for the trace analysis of pyruvic acid in biological fluids

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dc.contributor.authorBrahman P.K.
dc.contributor.authorPandey N.
dc.contributor.authorTopkaya S.N.
dc.contributor.authorSinghai R.
dc.date.accessioned2019-10-27T08:21:11Z
dc.date.available2019-10-27T08:21:11Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractWe propose development of a novel electrochemical sensor based on fullerene-multi-walled carbon nanotubes composite film for the sensitive determination of the pyruvic acid in biological fluids. The developed sensor was characterized by cyclic voltammetry. The nanocomposite film of C60-MWCNTs on GCE exhibits electrocatalytic activity towards pyruvic acid reduction and also decreases the reduction overpotential. The influence of the optimization parameters such as pH and effect of loading of composite mixture of C60 and MWCNTs on the electrochemical performance of the sensor were evaluated. Various kinetic parameters such as electron transfer number (n=2), proton transfer number (m=2) and charge transfer coefficient (?=0.56) were also calculated. Under optimized conditions, the squarewave reduction peak current was linear over the concentration range of 2.0-55 nM with the detection and quantification limit of 0.1 nM and 0.8 nM respectively. The fabricated sensor was successfully applied to the detection of pyruvic acid in biological samples with good recovery ranging from 97.6% to 103.6%. © 2014 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScience and Engineering Research Board: SB/FT/CS-019/2014en_US
dc.description.sponsorshipThe authors are thankful to the Head, Department of Chemistry, K L University, Green fields, Vaddeswaram, Guntur (A.P.) India for providing necessary laboratory facilities and the Science and Engineering Research Board , (Grant No. SB/FT/CS-019/2014 ) New Delhi for financial support under its Fastrack Young Scientists Scheme. --en_US
dc.identifier.doi10.1016/j.talanta.2014.10.054en_US
dc.identifier.endpage559en_US
dc.identifier.issn0039-9140
dc.identifier.pmid25618707en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage554en_US
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2014.10.054
dc.identifier.urihttps://hdl.handle.net/11454/25943
dc.identifier.volume134en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofTalantaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC60-MWCNTsen_US
dc.subjectElectrocatalyticen_US
dc.subjectElectrochemical sensoren_US
dc.subjectNanocomposite filmen_US
dc.subjectPyruvic aciden_US
dc.titleFullerene-C60-MWCNT composite film based ultrasensitive electrochemical sensing platform for the trace analysis of pyruvic acid in biological fluidsen_US
dc.typeArticleen_US

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