Invitro fertilization-induced pregnancies predispose to gastroesophageal reflux disease

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dc.contributor.authorTuran, Ilker
dc.contributor.authorKitapcioglu, Gul
dc.contributor.authorGoker, Ege Tavmergen
dc.contributor.authorSahin, Gulnaz
dc.contributor.authorBor, Serhat
dc.date.accessioned2019-10-27T23:10:38Z
dc.date.available2019-10-27T23:10:38Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Women conceiving following invitro fertilization (IVF) likely have a variety of risk factors that predispose them to gastroesophageal reflux disease (GERD) in the future. Objective We aimed to investigate whether pregnancy through IVF may predispose to subsequent GERD compared with pregnancies without IVF. We also evaluate whether twin IVF pregnancies lead to additional risk for having GERD compared with singleton IVF pregnancies. Methods A validated reflux questionnaire was administered to 156 women with singleton (n=102) or twin (n=54) IVF birth (IVF group) and 111 women with a naturally conceived singleton birth (control group). All women included in the study were primiparas who had given birth at least 1 year prior to data collection. The diagnosis of GERD was based on the occurrence of typical symptoms (heartburn, regurgitation, or both) at least once a week. Results The prevalence of GERD was 13.5% and 4.5% in IVF and control groups (p=0.015); in the IVF group, this was slightly higher, but not statistically significant, in women with twin compared with singleton pregnancies (14.8% vs. 12.7%, p=0.749). Logistic regression analysis showed that IVF was strongly associated with subsequent GERD (OR, 3.30; 95% CI 1.20-9.04; p=0.02). Conclusion The risk of developing GERD at least 1 year after delivery increased following IVF. Long-term follow-up studies are required to determine whether therapy during pregnancy can prevent this risk.en_US
dc.identifier.doi10.1177/2050640615597836en_US
dc.identifier.endpage228en_US
dc.identifier.issn2050-6406
dc.identifier.issn2050-6414
dc.identifier.issue2en_US
dc.identifier.pmid27087950en_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://doi.org/10.1177/2050640615597836
dc.identifier.urihttps://hdl.handle.net/11454/52934
dc.identifier.volume4en_US
dc.identifier.wosWOS:000373229600009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofUnited European Gastroenterology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastroesophageal reflux diseaseen_US
dc.subjectheartburnen_US
dc.subjectregurgitationen_US
dc.subjectinvitro fertilizationen_US
dc.subjectpregnancyen_US
dc.titleInvitro fertilization-induced pregnancies predispose to gastroesophageal reflux diseaseen_US
dc.typeArticleen_US

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