Comparison of Vesikari and Clark scales regarding the definition of severe rotavirus gastroenteritis in children

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dc.contributor.authorAslan, Asli
dc.contributor.authorKurugol, Zafer
dc.contributor.authorCetin, Hulya
dc.contributor.authorKarakaslilar, Sabahat
dc.contributor.authorKoturoglu, Guldane
dc.date.accessioned2019-10-27T20:26:01Z
dc.date.available2019-10-27T20:26:01Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Two clinical severity scales, the Vesikari scale and the Clark scale, are commonly used to assess the efficacy of rotavirus vaccines. The results obtained using the two severity scales differ significantly and hamper comparisons. The aim of this study was to compare the Clark and Vesikari scales and to determine whether modified classifications would provide a better correlation between the two scales. Methods: The severity of rotavirus gastroenteritis was assessed for each child using both the Vesikari and Clark scales. To make a statistical comparison between the two scales, the classifications were modified. Results: In total, 200 children with rotavirus gastroenteritis were evaluated. Of these, 57% were classified as severe by the Vesikari scale, and only 1.5% by the Clark scale (p < 0.001). When the Clark three-category scale was transformed into a two-category scale by merging mild and moderate categories as non-severe, a good correlation with the Vesikari scale still could not be found. Using the median of the severity scores as the severity threshold did not provide a better correlation between the two scales. Transforming the Vesikari two-category scale into a three-category scale by further subdividing the severe category into two parts, as moderate and severe (>= 16), provided a better correlation between the two severity scales, but still did not achieve a good level of agreement. Conclusions: The Clark and Vesikari scales differ significantly in the definition of severe gastroenteritis. Even the attempts at reclassifying the scales did not achieve a good correlation.en_US
dc.identifier.doi10.3109/00365548.2014.994186en_US
dc.identifier.endpage337en_US
dc.identifier.issn2374-4235
dc.identifier.issn2374-4243
dc.identifier.issue5en_US
dc.identifier.pmid25715939en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage332en_US
dc.identifier.urihttps://doi.org/10.3109/00365548.2014.994186
dc.identifier.urihttps://hdl.handle.net/11454/42288
dc.identifier.volume47en_US
dc.identifier.wosWOS:000354612900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInfectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClark scaleen_US
dc.subjectsevere rotavirus gastroenteritisen_US
dc.subjectvaccine efficacyen_US
dc.subjectVesikari scaleen_US
dc.titleComparison of Vesikari and Clark scales regarding the definition of severe rotavirus gastroenteritis in childrenen_US
dc.typeArticleen_US

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