Nosocomial Non-fermentative gram negative bacteria bloodstream infections in children; Risk factors and clinical outcomes of carbapenem resistance

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dc.contributor.authorOzenen, Gizem Guner
dc.contributor.authorBal, Zumrut Sahbudak
dc.contributor.authorUmit, Zuhal
dc.contributor.authorAvcu, Gulhadiye
dc.contributor.authorTekin, Duygu
dc.contributor.authorKurugol, Zafer
dc.contributor.authorOzkinay, Ferda
dc.date.accessioned2021-05-03T20:21:27Z
dc.date.available2021-05-03T20:21:27Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Non-fermentative Gram-negative bacterias (NFGNBs) are a major cause of life threatening infections in hospitalized children. in this study, we aimed to evaluate the demographic and clinical characteristics of NFGNBs infections and identify the risk factors and outcomes of bloodstream infections (BSIs) caused by carbapenem-resistant (CR) NFGNBs infections. Methods: A retrospective cohort was designed to evaluate the patients with a BSI caused by NFGNBs between in January 2014 and December 2017. Results: A total of 131 episodes from 115 patients were evaluated. The mean age of the patients was 4.79 +/-(4.74) year. The most commonly isolated NFGNBs species was Acinetobacter spp. (35.9%), Pseudomonas spp. (34.4%), and Stenotrophomonas maltophilia (13%). The rate of carbapenem-resistance was 38.2% in Acinetobacter spp. and 26.6% in Pseudomonas spp. The comparison of CR group with carbapenem-susceptible (CS) group showed statistical significance for the length of hospital stay prior to onset of infection and total hospital stay (P values were 0.001, 0.008). Based on the univariate analysis, requirement of mechanical ventilation, central venous catheter, nasogastric tube, Foley catheter, severe neutropenia (<100/mm3), prolonged neutropenia (>14 days), prior intensive care unit admission and prior antimicrobial treatment (carbapenems, colistin, glycopeptide) were more common in carbapenemresistant NFGNBs infections (P values are 0.001, 0.012, 0.000, 0.005, 0.042, 0.027, 0.007, 0.007). in patients with NFGNBs infections 14-day and 30-day mortality rates were %16.8 and 21.4%. Conclusion: CR infections were more common in children with prolonged and severe neutropenia. Prior antimicrobial use and intensive care unit admission were more common in CR infections. (c) 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jiac.2020.12.024en_US
dc.identifier.endpage735en_US
dc.identifier.issn1341-321X
dc.identifier.issn1437-7780
dc.identifier.issue5en_US
dc.identifier.pmid33454215en_US
dc.identifier.scopus2-s2.0-85099300102en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage729en_US
dc.identifier.urihttps://doi.org/10.1016/j.jiac.2020.12.024
dc.identifier.urihttps://hdl.handle.net/11454/69321
dc.identifier.volume27en_US
dc.identifier.wosWOS:000631034800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Infection and Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbapenem resitanceen_US
dc.subjectNon-fermentative gram negative bacteriaen_US
dc.subjectPediatricen_US
dc.titleNosocomial Non-fermentative gram negative bacteria bloodstream infections in children; Risk factors and clinical outcomes of carbapenem resistanceen_US
dc.typeArticleen_US

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