Circulating insulin-like peptide 5 levels and its association with metabolic and hormonal parameters in women with polycystic ovary syndrome

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dc.contributor.authorBicer, M.
dc.contributor.authorAlan, M.
dc.contributor.authorAlarslan, P.
dc.contributor.authorGuler, A.
dc.contributor.authorKocabas, G. U.
dc.contributor.authorImamoglu, C.
dc.contributor.authorAksit, M.
dc.contributor.authorBozkaya, G.
dc.contributor.authorIsil, A. M.
dc.contributor.authorBaloglu, A.
dc.contributor.authorAslanipoiur, B.
dc.contributor.authorCalan, Mehmet
dc.date.accessioned2019-10-27T09:46:01Z
dc.date.available2019-10-27T09:46:01Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractPurposeInsulin-like peptide 5 (INSL5) is a gut peptide hormone that is a member of relaxin/insulin superfamily. Growing evidence implicates the crucial role of the peptide in some metabolisms including food intake, glucose homeostasis and reproductive system. Polycystic ovary syndrome (PCOS) is involved in both reproductive and metabolic issues. The aim of the study was determination of circulating levels of INSL5 alteration in women with PCOS and evaluation of the relationship between INSL5 and hormonal-metabolic parameters as well as carotid intima media thickness (cIMT).MethodsA total of 164 subjects were recruited in this cross-sectional study (82 women with PCOS and 82 age- and BMI-matched controls). Circulating INSL5 levels were assessed via ELISA method. High-resolution B-mode ultrasound was used to measure cIMT. The hormonal and metabolic parameters of the recruited subjects were determined.ResultsCirculating INSL5 levels were significantly elevated in women with PCOS compared to controls (27.637.74 vs. 19.90 +/- 5.85ng/ml, P<0.001). The mean values of INSL5 were significantly higher in overweight subjects compared to lean weight subjects in both groups. The women with PCOS having insulin resistance have increased INSL5 compared to those of PCOS subjects without insulin resistance. INSL5 is associated with insulin resistance, BMI, luteinizing hormone and free androgen index. Multivariate logistic regression analyses revealed that the odds ratio for having PCOS in the highest tertile of INSL5 was higher than in the lowest tertile.Conclusions PCOS subjects exhibited an elevation in circulating INSL5 levels along with a link between INSL5 level induction and metabolic-hormonal parameters.en_US
dc.identifier.doi10.1007/s40618-018-0917-xen_US
dc.identifier.endpage312en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue3en_US
dc.identifier.pmid29956214en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage303en_US
dc.identifier.urihttps://doi.org/10.1007/s40618-018-0917-x
dc.identifier.urihttps://hdl.handle.net/11454/29219
dc.identifier.volume42en_US
dc.identifier.wosWOS:000459901200006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectInsulin-like peptide 5en_US
dc.subjectInsulin resistanceen_US
dc.subjectBody mass indexen_US
dc.subjectCarotid intima media thicknessen_US
dc.titleCirculating insulin-like peptide 5 levels and its association with metabolic and hormonal parameters in women with polycystic ovary syndromeen_US
dc.typeArticleen_US

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