LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS

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dc.contributor.authorTurkoglu, Oya
dc.contributor.authorEmingil, Gulnur
dc.contributor.authorEren, Gulnihal
dc.contributor.authorAtmaca, Harika
dc.contributor.authorKutukculer, Necil
dc.contributor.authorAtilla, Gul
dc.date.accessioned2019-10-27T11:21:00Z
dc.date.available2019-10-27T11:21:00Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: LL-37 is an antimicrobial peptide which plays an important role in the innate immunity. The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues. Materials and Methods: Forty middle-aged adults (20 healthy controls and 20 with gingivitis) and 41 younger adults (20 healthy controls and 21 with gingivitis) were included in the present study. Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. LL-37 levels in the GCF were analyzed by enzyme-linked immunosorbent assay. Results: No significant differences were observed in the GCF LL-37 levels between young healthy and middle-aged healthy subjects. Also, there were no significant differences in GCF LL-37 levels between young and middle-aged gingivitis subjects. However, gingivitis groups had significantly higher GCF LL-37 levels than healthy groups (p<0.001). Correlation analysis demonstrated no significant correlation between age and GCF LL-37 levels neither in healthy nor in gingivitis groups. Conclusion: The levels of LL-37 in GCF increase in the presence of gingival inflammation, however, this does not vary according to subjects being young or middle-aged.en_US
dc.description.sponsorshipEge University Research FoundationEge University [2012/DIS/019]en_US
dc.description.sponsorshipThis study has been supported by a research grant from Ege University Research Foundation (project no : 2012/DIS/019).en_US
dc.identifier.doi10.17096/jiufd.42354en_US
dc.identifier.endpage21en_US
dc.identifier.issn2149-2352
dc.identifier.issn2149-4592
dc.identifier.issue1en_US
dc.identifier.pmid28955581en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.17096/jiufd.42354
dc.identifier.urihttps://hdl.handle.net/11454/32892
dc.identifier.volume51en_US
dc.identifier.wosWOS:000408113400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIstanbul Univ, Fac Dentistryen_US
dc.relation.ispartofJournal of Istanbul University Faculty of Dentistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCathelicidin LL-37en_US
dc.subjectantimicrobial peptideen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectgingivitisen_US
dc.subjectageen_US
dc.titleLEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITISen_US
dc.typeArticleen_US

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