Effect of the model of early atherosclerosis on systemic hemodynamic parameters in rabbits [Tavşanlarda erken dönem ateroskleroz modelinin sistemik hemodinamik parametreler üzerindeki etkisi]

Basit Öğe Kaydı
dc.contributor.authorTürkseven S.
dc.contributor.authorYasa M.
dc.date.accessioned2019-10-27T00:11:36Z
dc.date.available2019-10-27T00:11:36Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate the effects of perivascular collar application, a model that induces intimal thickening seen in early atherosclerosis, on systemic hemodynamic parameters of rabbits. Rabbits were divided into two groups. In the first group, on the 1st day of the experiment (collared group, n=10), a soft silicone collar was implanted around the left carotid artery. The second group (perivascular manipulation group, n=10), served as control, was subjected only to perivascular manipulation on their left carotid artery without implanting the collar. Hemodynamic parameters of the rabbits were measured for half an hour on the first day and the final day (day 15) before the surgical operation. Statistical analysis was carried out by Wilcoxon signed rank test. A p value of <0.05 was considered statistically significant. This study has shown that neither collar implantation nor the perivascular manipulation affected the systemic hemodynamic parameters. In the collared group, positioning of the collar around the carotid artery resulted in an increase in intimal cross sectional area as compared to the normal arteries (0.091±0.015 mm vs 0.009±0.000 mm2, respectively, p=0.000, n=10). However, perivascular manipulation did not alter intimali cross sectional area (normal 0.009±0.001 mm2, manipulation 0.008± 0.001 mm2, p=0.172, n=7). In this model, a significant relationship between collar-induced intimal thickening and systemic hemodynamic parameters has not been found. Systemic hemodynamic parameters may not account for intimal thickening in this model. © Gülhane Askeri Tip Akademial 2005.en_US
dc.identifier.endpage285en_US
dc.identifier.issn1302-0471
dc.identifier.issn1302-0471en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage282en_US
dc.identifier.urihttps://hdl.handle.net/11454/22203
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherGulhane Askeri Tip Akademisien_US
dc.relation.ispartofGulhane Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood pressureen_US
dc.subjectCarotid arteryen_US
dc.subjectPerivascular silicone collaren_US
dc.subjectRabbiten_US
dc.titleEffect of the model of early atherosclerosis on systemic hemodynamic parameters in rabbits [Tavşanlarda erken dönem ateroskleroz modelinin sistemik hemodinamik parametreler üzerindeki etkisi]en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu