Effect of the model of early atherosclerosis on systemic hemodynamic parameters in rabbits [Tavşanlarda erken dönem ateroskleroz modelinin sistemik hemodinamik parametreler üzerindeki etkisi]
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gulhane Askeri Tip Akademisi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The purpose of this study was to investigate the effects of perivascular collar application, a model that induces intimal thickening seen in early atherosclerosis, on systemic hemodynamic parameters of rabbits. Rabbits were divided into two groups. In the first group, on the 1st day of the experiment (collared group, n=10), a soft silicone collar was implanted around the left carotid artery. The second group (perivascular manipulation group, n=10), served as control, was subjected only to perivascular manipulation on their left carotid artery without implanting the collar. Hemodynamic parameters of the rabbits were measured for half an hour on the first day and the final day (day 15) before the surgical operation. Statistical analysis was carried out by Wilcoxon signed rank test. A p value of <0.05 was considered statistically significant. This study has shown that neither collar implantation nor the perivascular manipulation affected the systemic hemodynamic parameters. In the collared group, positioning of the collar around the carotid artery resulted in an increase in intimal cross sectional area as compared to the normal arteries (0.091±0.015 mm vs 0.009±0.000 mm2, respectively, p=0.000, n=10). However, perivascular manipulation did not alter intimali cross sectional area (normal 0.009±0.001 mm2, manipulation 0.008± 0.001 mm2, p=0.172, n=7). In this model, a significant relationship between collar-induced intimal thickening and systemic hemodynamic parameters has not been found. Systemic hemodynamic parameters may not account for intimal thickening in this model. © Gülhane Askeri Tip Akademial 2005.
Açıklama
Anahtar Kelimeler
Blood pressure, Carotid artery, Perivascular silicone collar, Rabbit
Kaynak
Gulhane Medical Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
47
Sayı
4
