Does the magnetic field of a magnetic stirrer in an optical aggregometer affect concurrent platelet aggregation?

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dc.contributor.authorSagdilek, Engin
dc.contributor.authorSebik, Oguz
dc.contributor.authorCelebi, Gurbuz
dc.date.accessioned2019-10-27T21:51:57Z
dc.date.available2019-10-27T21:51:57Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractPlatelets are subjected to extremely low frequency electromagnetic fields during standard aggregometry measurements owing to the use of a magnetic stir bar in the instrument. This study evaluates the effects of this magnetic field exposure on platelet aggregation by comparing the results obtained in a modified aggregometer. Blood samples from healthy volunteers were anticoagulated using citrate or heparin. Platelet-rich plasma (PRP) samples were prepared. A mechanical stirring device was attached to the aggregometer instead of the magnetic stir bar system. The PRP samples were stirred using a stirring rod tip that did not produce any magnetic fields in one channel of the aggregometer; in the other channel, a stirring rod carrying a small magnet at its tip was used. As a result, a magnetic field in the extremely low frequency range and in the amplitude range of 1.9-65mT was applied to the platelets assigned to the channel where the magnetic stirring rod tip was used. Aggregation was induced using adenosine diphosphate (ADP), collagen, or epinephrine. The slopes, maximum aggregation values, and areas under the aggregation curves were compared between the magnetic and neutral stirring rod tip groups. For samples stirred with the magnetic stirring rod tip, a significant decrease was observed in 12 of the 14 parameters evaluated for aggregations induced with ADP or collagen compared to the neutral stirring rod tip, regardless of the method used for anticoagulation. This observation indicates that the magnetic stir bars used in standard aggregometry may significantly alter aggregation parameters and platelets may be possible targets of electromagnetic fields. Bioelectromagnetics 34:349-357, 2013. (c) 2012 Wiley Periodicals, Inc.en_US
dc.description.sponsorshipUludag University Scientific Research UnitUludag University [T-2008/47]; Ege University Commission for Scientific Research ProjectsEge University [2008-TIP-013]en_US
dc.description.sponsorshipGrant sponsor: Uludag University Scientific Research Unit; grant number: T-2008/47; grant sponsor: Ege University Commission for Scientific Research Projects; grant number: AREL Project Number: 2008-TIP-013.en_US
dc.identifier.doi10.1002/bem.21785en_US
dc.identifier.endpage357en_US
dc.identifier.issn0197-8462
dc.identifier.issue5en_US
dc.identifier.pmid23436227en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage349en_US
dc.identifier.urihttps://doi.org/10.1002/bem.21785
dc.identifier.urihttps://hdl.handle.net/11454/47409
dc.identifier.volume34en_US
dc.identifier.wosWOS:000319965000002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofBioelectromagneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectELF-EMFen_US
dc.subjectplateletsen_US
dc.subjectmodified aggregometryen_US
dc.subjectstir baren_US
dc.titleDoes the magnetic field of a magnetic stirrer in an optical aggregometer affect concurrent platelet aggregation?en_US
dc.typeArticleen_US

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