Local recurrence outcomes after breast conserving surgery and adjuvant radiotherapy in ductal carcinoma in situ of the breast and a comparison with ECOG E5194 study

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dc.contributor.authorAkagunduz, Ozlem Ozkaya
dc.contributor.authorErgen, Arzu
dc.contributor.authorErpolat, Petek
dc.contributor.authorGultekin, Melis
dc.contributor.authorYildirim, Berna Akkus
dc.contributor.authorParvizi, Murteza
dc.contributor.authorIkiz, Didem
dc.contributor.authorOksuz, Didem Colpan
dc.contributor.authorOnal, Cem
dc.contributor.authorYildiz, Ferah
dc.contributor.authorOzsaran, Zeynep
dc.date.accessioned2019-10-27T10:00:31Z
dc.date.available2019-10-27T10:00:31Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: Turkish Radiation Oncology Study Group investigated local recurrence rates and prognostic factors in patients with ductal carcinoma in situ (DCIS) of the breast treated with breast conservative surgery (BCS) followed by radiotherapy (RT) and Eastern Cooperative Oncology Group (ECOG) Study E5194 were compared with the original study. Patients and methods: Totally 252 patients were evaluated retrospectively. Prognostic factors that might influence local control (age, nuclear grade, comedo necrosis, surgical margins, tumor size, hormone receptor status) were compared. The eligibility criteria of ECOG 5194 were stratified into two groups as in the original study and were compared for local control. Results: The median follow-up time was 59 (21-220) months. Local recurrence was observed in 9 patients (3.6%) who had invasive carcinoma (3 patients) and DCIS (6 patients). Ten years local control rates was 91.8% respectively. We found that the risk of ipsilateral breast recurrence was significantly higher in women younger than 50 years old (p = 0.016). In addition, a statistically significant trend was found in patients with tumor larger than 1 cm and HER2 positive tumors (p = 0.051, p = 0.068 respectively). When 12-year results were compared with the ECOG 5194, adjuvant RT produced an absolute difference of 11% in low-intermediate and 20% in high grade in local control. Conclusion: In our study, the 10-year local control rate was 92% and younger than 50 years old was the most important unfavorable prognostic factor for local recurrence. There was provided 20% absolute local control with adjuvant radiotherapy which eligibility criteria of ECOG 5194 high grade group. (C) 2018 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.breast.2018.08.094en_US
dc.identifier.endpage14en_US
dc.identifier.issn0960-9776
dc.identifier.issn1532-3080
dc.identifier.pmid30121548en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://doi.org/10.1016/j.breast.2018.08.094
dc.identifier.urihttps://hdl.handle.net/11454/29739
dc.identifier.volume42en_US
dc.identifier.wosWOS:000448315600003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofBreasten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDuctal carcinoma in situen_US
dc.subjectRadiotherapyen_US
dc.subjectLocal controlen_US
dc.subjectIpsilateral breast recurrenceen_US
dc.subjectPrognostic factors for local controlen_US
dc.titleLocal recurrence outcomes after breast conserving surgery and adjuvant radiotherapy in ductal carcinoma in situ of the breast and a comparison with ECOG E5194 studyen_US
dc.typeArticleen_US

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