Chemical constituents and in vitro biological activities of Eremurus spectabilis leaves

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dc.contributor.authorKarakaya, Leyla
dc.contributor.authorAkgul, Yurdanur
dc.contributor.authorNalbantsoy, Ayse
dc.date.accessioned2019-10-27T11:21:34Z
dc.date.available2019-10-27T11:21:34Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractIn the present study, phytochemical investigation of the young leaves of Eremurus spectabilis let to the isolation six compounds (1-6). Their structure was determined by spectroscopic analysis and comparison with the literature data. All compounds were isolated for the first time from E. spectabilis. Isolated compounds and prepared extracts did not show cytotoxic activity against HeLa (Human cervix adenocarcinoma), A-549 (Human alveolar adenocarcinoma), MCF-7 (Human breast adenocarcinoma), mPANC96 (Human pancreas adenocarcinoma), U87MG (Glioblastoma), PC3 (Prostate), CaCo-2 (Colon), HEK293 (Human embryonic kidney cells) cell lines. RAW 264.7 (murine macrophage cell lines) was used to determine the inhibition levels of inducible nitric oxide synthase (iNOS).The hexane extract was found to be active in terms of inhibition of iNOS (IC50: 25g/ml). [GRAPHICS] .en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK]Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115Z012]; Research Grant Office of Ege University Izmir TurkeyEge University [2016/BIL/005]en_US
dc.description.sponsorshipThis research was supported by the Scientific and Technological Research Council of Turkey [grant number TUBITAK-No: 115Z012] and the Research Grant Office of Ege University Izmir Turkey [grant number 2016/BIL/005].en_US
dc.identifier.doi10.1080/14786419.2017.1292268en_US
dc.identifier.endpage1791en_US
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.issue15en_US
dc.identifier.pmid28278652en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1786en_US
dc.identifier.urihttps://doi.org/10.1080/14786419.2017.1292268
dc.identifier.urihttps://hdl.handle.net/11454/32928
dc.identifier.volume31en_US
dc.identifier.wosWOS:000404789700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEremurus spectabilisen_US
dc.subjectIsolated compoundsen_US
dc.subjectCytotoxicity and iNOS activitiesen_US
dc.titleChemical constituents and in vitro biological activities of Eremurus spectabilis leavesen_US
dc.typeArticleen_US

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