The oxytocin receptor gene polymorphism -rs237902- is associated with the severity of autism spectrum disorder: A pilot study

Basit Öğe Kaydı
dc.contributor.authorOcakoglu, Fevzi Tuna
dc.contributor.authorKose, Sezen
dc.contributor.authorOzbaran, Burcu
dc.contributor.authorOnay, Huseyin
dc.date.accessioned2019-10-27T10:46:12Z
dc.date.available2019-10-27T10:46:12Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Previous studies showed the association of Autism Spectrum Disorder (ASD) and oxytocin receptor (OXTR) gene. We aimed to explore the OXTR gene single nucleotide polymorphisms (SNPs) across the ASD severity categories based on DSM-5. Method: The whole encoding regions of the human OXTR gene were sequenced to identify the SNPs in 100 Turkish children with ASD. Genotypes of detected SNPs were also compared with the Childhood Autism Rating Scale (CARS) scores. Results: Disease severity of the patients carrying GA and AA genotypes (GA/AA) of rs237902 were found more severe compared to those carrying GG genotype (chi(2) = 6.456, df = 2, p = .040). This finding was more powerful in boys (chi(2) = 9.288, df = 2, p = .010). Similarly, GA/AA genotypes of rs237902 were found associated with higher CARS scores in boys (U = 650.5, r = 0.24, p = .021). Conclusion: Significant relationship between the ASD severity categories of DSM-5 and rs237902 was shown for the first time.en_US
dc.description.sponsorshipCoordinator Department of Ege University Scientific Research Projects [2016-TIP-025]en_US
dc.description.sponsorshipThis study was funded by the Coordinator Department of Ege University Scientific Research Projects. (The project number: 2016-TIP-025).en_US
dc.identifier.doi10.1016/j.ajp.2018.01.002en_US
dc.identifier.endpage149en_US
dc.identifier.issn1876-2018
dc.identifier.issn1876-2026
dc.identifier.pmid29428512en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage142en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajp.2018.01.002
dc.identifier.urihttps://hdl.handle.net/11454/31264
dc.identifier.volume31en_US
dc.identifier.wosWOS:000429590000047en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofAsian Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutism spectrum disorderen_US
dc.subjectOxytocinen_US
dc.subjectOxytocin receptor geneen_US
dc.subjectPolymorphismen_US
dc.subjectAutism severityen_US
dc.titleThe oxytocin receptor gene polymorphism -rs237902- is associated with the severity of autism spectrum disorder: A pilot studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu