Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: Implications of their relative ratio

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dc.contributor.authorBostanci N.
dc.contributor.authorIlgenli T.
dc.contributor.authorEmingil G.
dc.contributor.authorAfacan B.
dc.contributor.authorHan B.
dc.contributor.authorTöz H.
dc.contributor.authorAtilla G.
dc.contributor.authorHughes F.J.
dc.contributor.authorBelibasakis G.N.
dc.date.accessioned2019-10-27T08:37:39Z
dc.date.available2019-10-27T08:37:39Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Receptor activator of NF-?B ligand (RANKL) and osteoprotegerin (OPG) are a system of molecules that regulate bone resorption. This study aims to compare the levels of RANKL, OPG and their relative ratio in gingival crevicular fluid (GCF) of healthy and periodontal disease subjects. Material and Methods: GCF was obtained from healthy (n = 21), gingivitis (n = 22), chronic periodontitis (n = 28), generalized aggressive periodontitis (n = 25) and chronic periodontitis subjects under immunosuppressant therapy (n = 11). RANKL and OPG concentrations in GCF were measured by enzyme-linked immunosorbent assays. Results: RANKL levels were low in health and gingivitis groups, but increased in all three forms of periodontitis. OPG levels were higher in health than all three periodontitis, or gingivitis groups. There were no differences in RANKL and OPG levels between chronic and generalized aggressive periodontitis groups, whereas these were lower in the immunosuppressed chronic periodontitis group. The RANKL/OPG ratio was significantly elevated in all three periodontitis forms, compared with health or gingivitis, and positively correlated to probing pocket depth and clinical attachment level. Conclusion: GCF RANKL and OPG levels were oppositely regulated in periodontitis, but not gingivitis, resulting in an enhanced RANKL/OPG ratio. This ratio was similar in all three periodontitis groups and may therefore predict disease occurrence. © 2007 Blackwell Munksgaard.en_US
dc.identifier.doi10.1111/j.1600-051X.2007.01061.xen_US
dc.identifier.endpage376en_US
dc.identifier.issn0303-6979
dc.identifier.issue5en_US
dc.identifier.pmid17355365en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage370en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-051X.2007.01061.x
dc.identifier.urihttps://hdl.handle.net/11454/27556
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone resorptionen_US
dc.subjectELISAen_US
dc.subjectGingival crevicular fluiden_US
dc.subjectOPGen_US
dc.subjectRANKLen_US
dc.titleGingival crevicular fluid levels of RANKL and OPG in periodontal diseases: Implications of their relative ratioen_US
dc.typeArticleen_US

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