Extramedullary Relapse in a CML Patient after Allogeneic Stem Cell Transplantation

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dc.contributor.authorYilmaz, Asu Fergun
dc.contributor.authorSoyer, Nur
dc.contributor.authorOzsan, Nazan
dc.contributor.authorCagirgan, Seckin
dc.contributor.authorGunes, Ajda
dc.contributor.authorComert, Melda
dc.contributor.authorSahin, Fahri
dc.contributor.authorSaydam, Güray
dc.contributor.authorGunel, Nur Selvi
dc.contributor.authorVural, Filiz
dc.date.accessioned2019-10-27T11:22:27Z
dc.date.available2019-10-27T11:22:27Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractMyeloid or granulocytic sarcoma (GS) is a tumoral lesion consisting of immature granulocytic cells. It is a rare entity during the course of CML patients especially after allogeneic stem cell transplantation (SCT). Relapse without bone marrow involvement is much rarer. We report a case of CML patient who relapsed with isolated granulocytic sarcoma after allogeneic SCT during cytogenetic and molecular remission. 28-year-old male was diagnosed as CML and allogeneic SCT was performed because of refractory disease to tyrosine kinase inhibitors. Complete cytogenetic and molecular response was achieved after allogeneic SCT followed by dasatinib treatment. Approximately 5 years after the transplantation, very rapidly progressive lesion was documented and diagnosed as GS although he was at molecular and cytogenetic remission. The patient died during chemotherapy due to sepsis. GS relapse after allogeneic SCT is a very rare type of relapse in CML patients with molecular and cytogenetic remission. Since it is a very aggressive disease with a poor prognosis, combined chemoradiotherapies with other possible options like DLI or second allogeneic SCT should be considered as soon as the diagnosis is confirmed.en_US
dc.identifier.doi10.1155/2017/6350267en_US
dc.identifier.endpage3en_US
dc.identifier.issn2090-6560
dc.identifier.issn2090-6579
dc.identifier.pmid28421151en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1155/2017/6350267
dc.identifier.urihttps://hdl.handle.net/11454/33036
dc.identifier.wosWOS:000396896500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofCase Reports in Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleExtramedullary Relapse in a CML Patient after Allogeneic Stem Cell Transplantationen_US
dc.typeArticleen_US

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