Laser-scribed Graphene Electrodes as an Electrochemical Immunosensing Platform for Cancer Biomarker 'eIF3d'

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dc.contributor.authorBalaban, Simge
dc.contributor.authorBeduk, Tutku
dc.contributor.authorDurmus, Ceren
dc.contributor.authorAydindogan, Eda
dc.contributor.authorSalama, Khaled Nabil
dc.contributor.authorTimur, Suna
dc.date.accessioned2021-05-03T20:33:17Z
dc.date.available2021-05-03T20:33:17Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstracteIF3d is a protein biomarker which has a potential for the diagnosis of various cancers. Herein, a bio-platform was constructed for eIF3d sensing by using LSG and surface functionalization with anti eIF3d antibody via EDC/NHS chemistry. Following the surface modifications, XPS and several electrochemical methods were used. Difference in the signals were related to biomarker amounts between 75-500 ng/mL. LOD was calculated as 50.4 ng/mL. Selectivity of biosensor was tested by using of various interference molecules. EIF3d was also successfully detected in synthetic biological samples. Thus, to the best of our knowledge, this study is one of the rare studies on use of LSGs in immunosensor studies.en_US
dc.description.sponsorshipKing Abdullah University of Science and Technology (KAUST), Saudi ArabiaKing Abdullah University of Science & Technologyen_US
dc.description.sponsorshipThe authors would like to express their acknowledgements to the financial support of funding from King Abdullah University of Science and Technology (KAUST), Saudi Arabia. Biosensing experiments as well as SEM and XPS analysis were conducted in Ege University, Central Research Test and Analysis Laboratory Application and Research Center (EGE-MATAL).en_US
dc.identifier.doi10.1002/elan.202060482
dc.identifier.endpage1080en_US
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issn1040-0397en_US
dc.identifier.issn1521-4109en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85099235117en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1072en_US
dc.identifier.urihttps://doi.org/10.1002/elan.202060482
dc.identifier.urihttps://hdl.handle.net/11454/69940
dc.identifier.volume33en_US
dc.identifier.wosWOS:000606525400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofElectroanalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLaser-scribed graphene electrodesen_US
dc.subjectCanceren_US
dc.subjectBiosensorsen_US
dc.subjectAffinity-based sensorsen_US
dc.subjectBiomarkersen_US
dc.subjectEIF3Den_US
dc.titleLaser-scribed Graphene Electrodes as an Electrochemical Immunosensing Platform for Cancer Biomarker 'eIF3d'en_US
dc.typeArticleen_US

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