Laser-scribed Graphene Electrodes as an Electrochemical Immunosensing Platform for Cancer Biomarker 'eIF3d'
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
eIF3d is a protein biomarker which has a potential for the diagnosis of various cancers. Herein, a bio-platform was constructed for eIF3d sensing by using LSG and surface functionalization with anti eIF3d antibody via EDC/NHS chemistry. Following the surface modifications, XPS and several electrochemical methods were used. Difference in the signals were related to biomarker amounts between 75-500 ng/mL. LOD was calculated as 50.4 ng/mL. Selectivity of biosensor was tested by using of various interference molecules. EIF3d was also successfully detected in synthetic biological samples. Thus, to the best of our knowledge, this study is one of the rare studies on use of LSGs in immunosensor studies.
Açıklama
Anahtar Kelimeler
Laser-scribed graphene electrodes, Cancer, Biosensors, Affinity-based sensors, Biomarkers, EIF3D
Kaynak
Electroanalysis
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
33
Sayı
4
