Detection of Pneumocystis jirovecii by PCR in patients with lung cancer: A preliminary study

Basit Öğe Kaydı
dc.authoridUnat, Omer Selim/0000-0002-5708-2233
dc.authorscopusid57971677500
dc.authorscopusid35334304100
dc.authorscopusid57932912200
dc.authorscopusid55070828100
dc.authorscopusid55665073900
dc.authorscopusid57551049200
dc.authorscopusid57226101931
dc.contributor.authorBagci, Ozlem Ulusan
dc.contributor.authorGuldaval, Filiz
dc.contributor.authorMuftuoglu, Can
dc.contributor.authorMert, Ufuk
dc.contributor.authorToz, Seray
dc.contributor.authorUnat, Damla Serce
dc.contributor.authorUnat, Omer Selim
dc.date.accessioned2024-08-25T18:38:53Z
dc.date.available2024-08-25T18:38:53Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Infection complications in lung cancer (LC), one of the most common cancers in the world, are still among the most important causes of death. Of them, P. jirovecii, which is as an opportunistic infection, causes a life-threatening type of pneumonia in cancer patients. This preliminary study aimed to determine the incidence and clinical status of P. jirovecii by PCR in lung cancer patients compared to the conventional method. Material and methods: Sixty-nine lung cancer patients and fSorty healthy individuals were included in the study. After sociodemographical and clinical features were recorded, sputum samples were collected from attenders. Firstly, microscopic examination was made with Gomori's methenamine silver stain and then PCR was performed.Results: P. jirovecii was detected in three of 69 lung cancer patients by PCR (4.3%), but not by microscopy. However, healthy individuals were negative for P. jirovecii by both methods. Based on clinical and radiologi-cal findings, P. jirovecii was evaluated as probable infection in one patient and colonization in the other two patients. Although PCR is more sensitive than conventional staining methods, it cannot distinguish probable and proven infections from pulmonary colonization.Discussion: It is important to evaluate the decision of infection together with laboratory, clinical and radiolog-ical findings. Moreover, PCR may enable to know the colonization and to take precautions such as prophy-laxis, due to the risk of colonization turning into an infection in immunocompromised patient groups. Further studies involving larger populations and evaluating the colonization-infection relationship in patients with solid tumors are needed.(c) 2023 SFMM. Published by Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipTUBITAK [120N924]en_US
dc.description.sponsorshipFunding This work is supported by TUBITAK with Project No: 120N924.en_US
dc.identifier.doi10.1016/j.mycmed.2023.101365
dc.identifier.issn1156-5233
dc.identifier.issn1773-0449
dc.identifier.issue2en_US
dc.identifier.pmid36871350en_US
dc.identifier.scopus2-s2.0-85149331510en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.mycmed.2023.101365
dc.identifier.urihttps://hdl.handle.net/11454/101182
dc.identifier.volume33en_US
dc.identifier.wosWOS:000962001800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMasson Editeuren_US
dc.relation.ispartofJournal De Mycologie Medicaleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectColonizationen_US
dc.subjectLung canceren_US
dc.subjectMicroscopyen_US
dc.subjectPneumocystis jiroveciien_US
dc.subjectSputumen_US
dc.subjectPolymerase chain reactionen_US
dc.subjectPolymerase-Chain-Reactionen_US
dc.subjectImmunocompromised Patientsen_US
dc.subjectNon-Hiven_US
dc.subjectPneumoniaen_US
dc.subjectColonizationen_US
dc.subjectDiagnosisen_US
dc.titleDetection of Pneumocystis jirovecii by PCR in patients with lung cancer: A preliminary studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu