Changes in vascularity of cartilage endplate of degenerated intervertebral discs in response to melatonin administration in rats

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dc.contributor.authorTurgut, M
dc.contributor.authorUslu, S
dc.contributor.authorUysal, A
dc.contributor.authorYurtseven, ME
dc.contributor.authorUstun, H
dc.date.accessioned2019-10-27T18:39:57Z
dc.date.available2019-10-27T18:39:57Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractWe carried out an experimental investigation of cartilage endplate vascularity of degenerated intervertebral discs produced by exogenous melatonin (MEL) treatment. Adult Swiss albino rats were divided into three groups: control, operated degeneration, and MEL treatment. There were five rats in each group and, using a posterior approach, cuts were made parallel to the endplates in the posterior annulus fibrosus in five consecutive intervertebral discs between the 5th and 10th vertebral segments of the rats' tails. At 8 weeks, five of these animals were treated with exogenous MEL (s.c. injection of 30 mug/100 g body weight daily for 4 weeks). In each experimental group, one animal was examined using CT scanner to study the density of the cartilage endplate of the disc. To evaluate the bone growth and vascularity of the cartilage endplate region, the animals were killed for subsequent histopathological evaluation. We found that the vascular channel counts and percentage areas from animals treated with MEL were significantly lower than from the operated degeneration animals. Accordingly, the density histogram in the MEL group showed a spike profile for both the vertebral body and the cartilage endplate, indicating an increase in the amount of higher density tissues in these regions. Our results demonstrate that the use of MEL reduces the cartilage endplate vascularity of degenerated intervertebral discs, suggesting that it may have an osteoinductive effect on bone formation. Further studies are needed to characterize fully the relevance of our findings for the treatment of disorders such as postmenopausal osteoporosis.en_US
dc.identifier.doi10.1007/s10143-003-0259-8en_US
dc.identifier.endpage138en_US
dc.identifier.issn0344-5607
dc.identifier.issn1437-2320
dc.identifier.issue2en_US
dc.identifier.pmid12962300en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://doi.org/10.1007/s10143-003-0259-8
dc.identifier.urihttps://hdl.handle.net/11454/36843
dc.identifier.volume26en_US
dc.identifier.wosWOS:000183722900009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurosurgical Reviewen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcartilage endplateen_US
dc.subjectintervertebral discen_US
dc.subjectmelatoninen_US
dc.subjectvascular channelsen_US
dc.subjectvertebral bodyen_US
dc.titleChanges in vascularity of cartilage endplate of degenerated intervertebral discs in response to melatonin administration in ratsen_US
dc.typeArticleen_US

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