Gingival crevicular fluid and serum levels of APRIL, BAFF and TNF-alpha in rheumatoid arthritis and osteoporosis patients with periodontal disease

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dc.contributor.authorGumus, Pinar
dc.contributor.authorBuduneli, Eralp
dc.contributor.authorBiyikoglu, Basak
dc.contributor.authorAksu, Kenan
dc.contributor.authorSarac, Fulden
dc.contributor.authorBuduneli, Nurcan
dc.contributor.authorLappin, David F.
dc.date.accessioned2019-10-27T22:07:54Z
dc.date.available2019-10-27T22:07:54Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: This study was performed to evaluate gingival crevicular fluid (GCF) and serum levels of a proliferation inducing ligand (APRIL) and B cell activating factor (BAFF) and compare this to differences between TNF-alpha levels in rheumatoid arthritis (RA), osteoporosis (OPR) and systemically healthy women with periodontal disease (SH). Design: Gingival crevicular fluid (GCF) and serum samples were obtained before any periodontal intervention from 17 RA, 19 OPR patients and 13 SH women with periodontitis. Full-mouth clinical periodontal measurements were recorded. APRIL, BAFF and TNF-alpha levels were determined by ELISA. Statistical analysis was performed using multivariate analysis, ANOVA and Spearman correlation. Results: Pocket depths differed in site-specific comparisons, but otherwise clinical measurements were similar in the three study groups. Multivariate least squares regression ANOVA adjusted for age and for plaque index indicated that total amounts of TNF-alpha and concentrations of TNF-alpha, BAFF and APRIL were significantly greater in the RA patients than in the SH group (p < 0.05), and GCF concentrations of BAFF were greater in OPR patients than in SH. Serum TNF-alpha and BAFF were significantly higher in the RA group compared to SH (p <0.05) and serum TNF-alpha was greater in RA than in OPR (p < 0.05). APRIL and BAFF correlated with RANKL levels in GCF and serum (p < 0.05). Conclusion: Despite long-term usage of anti-inflammatory drugs in the RA and OPR patients, increased TNF-family cytokines, might suggest that these patients have a propensity to overproduce these inflammatory mediators but whether this results from greater disease activity or contribute to greater disease activity remains moot. (C) 2013 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipEge University Research Foundation, Izmir, TurkeyEge University [2007 Dis 025]; University of Glasgowen_US
dc.description.sponsorshipThis study was supported by the grant from the Ege University Research Foundation (2007 Dis 025), Izmir, Turkey and by funds from the University of Glasgow.en_US
dc.identifier.doi10.1016/j.archoralbio.2013.07.010en_US
dc.identifier.endpage1308en_US
dc.identifier.issn0003-9969
dc.identifier.issn1879-1506
dc.identifier.issue10en_US
dc.identifier.pmid24011305en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1302en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2013.07.010
dc.identifier.urihttps://hdl.handle.net/11454/49096
dc.identifier.volume58en_US
dc.identifier.wosWOS:000325236600005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectOsteoporosisen_US
dc.subjectTNF-family cytokines serumen_US
dc.subjectGingival crevicular fluiden_US
dc.titleGingival crevicular fluid and serum levels of APRIL, BAFF and TNF-alpha in rheumatoid arthritis and osteoporosis patients with periodontal diseaseen_US
dc.typeArticleen_US

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