How Safe Is the Use of Intrathecal Vancomycin?

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dc.authoridAldag, Ceyda/0000-0003-3130-4739
dc.authoridSandal, Evren/0000-0001-9268-1744
dc.authorscopusid57430807700
dc.authorscopusid21734496800
dc.authorscopusid57208213974
dc.authorscopusid57208215503
dc.authorscopusid55318033800
dc.authorscopusid57190794517
dc.authorscopusid57216455613
dc.contributor.authorDemir, Abdulkadir
dc.contributor.authorCamlar, Mahmut
dc.contributor.authorKuscu, Gokce Ceren
dc.contributor.authorGurel, Cevik
dc.contributor.authorOltulu, Fatih
dc.contributor.authorOren, Merve
dc.contributor.authorAldag, Ceyda
dc.date.accessioned2023-01-12T19:58:28Z
dc.date.available2023-01-12T19:58:28Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBACKGROUND: Central nervous system infection after neurosurgical procedures is a severe complication with high morbidity rates and sometimes mortality. Our experimental study aimed to investigate the biochemical and histopathologic effects of vancomycin on neural tissues when applied to the cisterna magna. METHODS: Wistar albino rats were randomly divided into 4 groups: Control (Group 1) and different vancomycin dose groups (Groups 2, 3, and 4). In Group 1, 0.1 mL cerebrospinal fluid was drained from the cisterna magna and 0.1 mL 0.9% NaCI (normal saline) was administered into the subarachnoid space. In the study groups, 0.1 mL cerebrospinal fluid was drained from the cisterna magna and 0.1 mg/200g rat per day (Group 2), 0.2 mg/200g rat per day (Group 3), and 0.4 mg/200g rat per day (Group 4) vancomycin were administered into the subarachnoid space for 7 days. All rats were sacrificed on the eighth day. Serum super-oxide dismutase and catalase levels were measured. Histopathologic and immunohistochemical analyses were conducted. RESULTS: The findings showed that the administration of 0.2 and 0.4 mg/kg doses had significant differences in superoxide dismutase and catalase activity compared with the controls (P < 0.05). These vancomycin doses also induced the apoptotic process, and the enzyme activity results correlated with immunohistochemical results. CONCLUSIONS: Dose-related neurotoxicity of intrathecal vancomycin was shown at the cellular level. The importance of dose regulation of intrathecal vancomycin has come into view. To our knowledge, this is the first study in the literature that has investigated the neurotoxic effects of vancomycin.en_US
dc.identifier.doi10.1016/j.wneu.2021.12.082
dc.identifier.endpageE60en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid34971834en_US
dc.identifier.scopus2-s2.0-85123688811en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE55en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2021.12.082
dc.identifier.urihttps://hdl.handle.net/11454/76914
dc.identifier.volume160en_US
dc.identifier.wosWOS:000820518700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntrathecalen_US
dc.subjectNeurotoxicityen_US
dc.subjectRaten_US
dc.subjectVancomycinen_US
dc.subjectIntraventricular Vancomycinen_US
dc.subjectMeningitisen_US
dc.subjectVentriculitisen_US
dc.subjectManagementen_US
dc.subjectInfectionen_US
dc.subjectLiveren_US
dc.titleHow Safe Is the Use of Intrathecal Vancomycin?en_US
dc.typeArticleen_US

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