How Safe is the Use of Intrathecal Fluorescein? An Experimental Study

Basit Öğe Kaydı
dc.contributor.authorÇamlar, Mahmut
dc.contributor.authorTürk, Çağlar
dc.contributor.authorOltulu, Fatih
dc.contributor.authorOren, Merve
dc.contributor.authorBuhur, Aylin
dc.contributor.authorYiğittürk, Gürkan
dc.contributor.authorGazioğlu, Nurperi
dc.date.accessioned2021-05-03T21:16:31Z
dc.date.available2021-05-03T21:16:31Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractAIM: To investigate the effects of fluorescein-sodium on neural tissues. MATERIAL and METHODS: Twenty-one Wistar rats were randomly divided into three experimental groups: control (group 1) and fluorescein-sodium groups with different doses (groups 2 and 3). In the control group, craniectomy following with durotomy was performed with the help of a loupe microscope, and a dry sponge was overlayed to the brain tissue. In the study groups, the open dura was covered with a sponge soaked with 0.02 mg (group 2) and with 0.2 mg (group 3) fluorescein sodium following craniectomy. Three weeks postoperatively, rats were sacrificed for the histopathologic evaluations. RESULTS: Fluorescein-induced apoptosis occurs in a dose-dependent manner in rats’ neurons. It was determined that neuron and neuroglial cell TUNEL staining was statistically different among the three groups (p<0.001). Our results indicated that fluorescein induces apoptosis, resulting in increased nuclear factor kappa beta (NF-??) expression in a dose-dependent manner. CONCLUSION: Fluorescein sodium is used frequently during surgery for CSF fistulas. However, information in the literature about its safety is insufficient. Our study holds promise for the development of new studies on the reliability of this agent.en_US
dc.identifier.doi10.5137/1019-5149.JTN.24085-18.3
dc.identifier.endpage554en_US
dc.identifier.issn1019-5149
dc.identifier.issue4en_US
dc.identifier.startpage549en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.24085-18.3
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpVMU9UZ3lNZz09
dc.identifier.urihttps://hdl.handle.net/11454/71926
dc.identifier.volume29en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleHow Safe is the Use of Intrathecal Fluorescein? An Experimental Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu