The Effect of Melatonin on a Dorsal Skin Flap Model

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dc.contributor.authorKerem, Hakan
dc.contributor.authorAkdemir, Ovunc
dc.contributor.authorAtes, Utku
dc.contributor.authorUyanikgil, Yigit
dc.contributor.authorSezer, Ebru Demirel
dc.contributor.authorBilkay, Ufuk
dc.contributor.authorTurgut, Mehmet
dc.contributor.authorSozmen, Eser
dc.contributor.authorSongur, Ecmel
dc.date.accessioned2019-10-27T22:15:52Z
dc.date.available2019-10-27T22:15:52Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Melatonin (Mel) has a very potent antioxidant activity, depending mainly on its capacity to act as an electron donor. Recently, the antioxidant property of Mel has been much emphasized. In this study, the dorsal skin flap model was used to investigate the effect of Mel in flap viability in rats. Material and Methods: Totally 28 Wistar Albino rats were divided into four groups: control group (C) (n = 7), local treatment group (L) (n = 7), systemic low-dose melatonin treatment group (LT) (n = 7), and systemic high-dose melatonin treatment group (HT) (n = 7). The necrosis rate of the skin flaps was observed seven days after the operation by a blinded observer. Oxidative stress was assessed by determining malondialdehyde (MDA) level, and effects of melatonin on antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) were measured. Vascularity, epithelial thickness, and fibroblast proliferation of dorsal skin flaps were assessed histologically. Results: Amount of MDA were found significantly lower (p < .05), and the flap viability, CAT, SOD, vascularity, fibroblast proliferation, and epithelial thickness were found significantly higher (p < .05) in groups HT than in groups C, L, and LT statistically. Conclusion: Our results showed that the usage on different doses of melatonin could play an important role in the process of flap viability and further studies will focus on these areas of interest.en_US
dc.identifier.doi10.3109/08941939.2013.835892en_US
dc.identifier.endpage64en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue2en_US
dc.identifier.pmid24063690en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.3109/08941939.2013.835892
dc.identifier.urihttps://hdl.handle.net/11454/50227
dc.identifier.volume27en_US
dc.identifier.wosWOS:000333394400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmelatoninen_US
dc.subjectflap viabilityen_US
dc.subjecthigh doseen_US
dc.subjectlow doseen_US
dc.subjectlocalen_US
dc.titleThe Effect of Melatonin on a Dorsal Skin Flap Modelen_US
dc.typeArticleen_US

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