Evaluation of the effects of radiotherapy to the chiasm and optic nerve by visual psychophysical and electrophysiologic tests in nasopharyngeal carcinoma

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dc.contributor.authorEsassolak, M
dc.contributor.authorKaragoz, U
dc.contributor.authorYalman, D
dc.contributor.authorKose, S
dc.contributor.authorAnacak, Y
dc.contributor.authorHaydaroglu, A
dc.date.accessioned2019-10-27T19:04:41Z
dc.date.available2019-10-27T19:04:41Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: To evaluate the effects of high-dose radiotherapy (RT) to the chiasm and optic nerves in locally advanced nasopharyngeal carcinoma patients by visual psychophysical and electrophysiologic tests. Methods and Materials: A series of visual tests, including visual evoked potentials (VEPs), contrast sensitivity, and visual field and visual acuity tests, were administered to 27 patients with locally advanced (T4) nasopharyngeal carcinoma who had undergone RT to high doses 6 to 74 months previously. As a control group, the same tests were administered to 40 unirradiated patients who had been referred to the ophthalmology department for any reason. Results: The median values of VEP latency, VEP amplitude, and contrast sensitivity and the rate of visual field defect were significantly worse in the RT group (p = 0.06, p <0.001, p <0.001, and p = 0.005, respectively). No dose-response relationship was found in any tests when 50 Gy was the cutoff value. However, a positive correlation between the interval after RT and VEP latency (r = 0.406, p = 0.003) and a negative correlation between the interval and contrast sensitivity (r = -0.499, p <0.001) was noted; no correlation could be established regarding VEP amplitude and the interval after RT. Conclusion: Radiation-induced injury to the anterior visual pathways could result in an increase in VEP latency and a decrease in VEP amplitude and contrast sensitivity. This injury seems to be a continuous process developing with time. (C) 2004 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.ijrobp.2003.08.014en_US
dc.identifier.endpage1146en_US
dc.identifier.issn0360-3016
dc.identifier.issue4en_US
dc.identifier.pmid15001256en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1141en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijrobp.2003.08.014
dc.identifier.urihttps://hdl.handle.net/11454/38227
dc.identifier.volume58en_US
dc.identifier.wosWOS:000220084200017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectradiation optic neuropathyen_US
dc.subjectvisual evoked potentialen_US
dc.subjectcontrast sensitivityen_US
dc.titleEvaluation of the effects of radiotherapy to the chiasm and optic nerve by visual psychophysical and electrophysiologic tests in nasopharyngeal carcinomaen_US
dc.typeArticleen_US

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