Evaluation of candidemia in children at a university hospital: A retrospective cohort
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Candidemia is a life-threatening infection in hospitalied children. This study aimed to evaluate candidemia's demographic and clinical characteristics and identify the risk factors and outcomes of Candida albicans (CA) and non-albicans Candida (NAC) spp. Methods: A retrospective cohort was designed to evaluate paediatric patients with candidemia between January 2008 and December 2020. Results: A total of 342 episodes in 311 patients were evaluated. The median age of the patients was 2.1 years (1 month–17 years and 6 months), and 59.6% were male. The prevalence of NAC (67.5%) candidemia was higher than that of CA (32.5%). The most commonly isolated Candida species was Candida parapsilosis (43.3%), followed by C. albicans (32.5%), Candida glabrata (6.1%) and Candida tropicalis (5.0%). The length of hospital stay prior to the positive culture and the total length of hospital stay were longer in the NAC group (p =.003 and p =.006). The neutrophil count was lower in the NAC group (p =.007). In the multivariate analysis, total parenteral nutrition, antifungal prophylaxis and a history of coagulase-negative staphylococci (CoNS) culture positivity in the past month were risk factors for developing candidemia due to NAC (p values were.003,.003 and.045). C. albicans and C. parapsilosis fluconazole resistance were 9.5% and 46.6%, respectively. The rates of amphotericin B resistance were 1.1% and 7.6% in C. albicans and C. parapsilosis, respectively. Mortality (14-day and 30-day) rates did not differ between the groups. Conclusions: A history of CoNS culture positivity in the past month, total parenteral nutrition, and antifungal prophylaxis increases the risk of NAC candidemia. © 2023 Wiley-VCH GmbH.
Açıklama
Anahtar Kelimeler
Candida albicans, Candidemia, fluconazole, non-albicans Candida, paediatrics, amphotericin B, amphotericin B lipid complex, anidulafungin, antibiotic agent, antineoplastic agent, caspofungin, echinocandin, fluconazole, immunosuppressive agent, itraconazole, micafungin, posaconazole, steroid, voriconazole, antifungal agent, adolescent, antifungal resistance, antifungal susceptibility, antifungal therapy, Article, bacterium culture, Candida, Candida albicans, Candida dubliniensis, Candida glabrata, Candida inconspicua, Candida intermedia, Candida parapsilosis, Candida tropicalis, candidemia, child, Clavispora lusitaniae, clinical feature, coagulase negative Staphylococcus, cohort analysis, controlled study, female, fungus culture, fungus isolation, hospitalized child, human, infection prevention, infection risk, Kluyveromyces marxianus, length of stay, major clinical study, male, medical history, Meyerozyma guilliermondii, monotherapy, mortality, neutropenia, neutrophil count, nonhuman, Pichia kudriavzevii, prevalence, prognosis, retrospective study, tertiary care center, total parenteral nutrition, treatment outcome, Turkey (republic), university hospital, Wickerhamomyces anomalus, Candida albicans, candidemia, microbial sensitivity test, microbiology, preschool child, risk factor, Antifungal Agents, Candida, Candida albicans, Candida parapsilosis, Candidemia, Child, Child, Preschool, Female, Hospitals, University, Humans, Male, Microbial Sensitivity Tests, Retrospective Studies, Risk Factors
Kaynak
Mycoses
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
66
Sayı
5
