Anthemis tricolor Containing Unusual Totarol with Cytotoxic and Acetylcholinesterase-Inhibitory Activity

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dc.authoridYucel, Yasemin Yucel/0000-0002-6595-6850
dc.contributor.authorYucel, Yasemin Yucel
dc.contributor.authorServi, Hueseyin
dc.contributor.authorPolatoglu, Kaan
dc.contributor.authorNalbantsoy, Ayse
dc.date.accessioned2024-08-31T07:47:00Z
dc.date.available2024-08-31T07:47:00Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractAnthemis tricolor is an endemic species of Cyprus, and there is very limited information on its chemistry and pharmacological activities. The study aims to identify the in-vitro cytotoxic and acetylcholinesterase activities of Anthemis tricolor. The compounds responsible for the activities were also identified. Potent extracts of A. tricolor were subjected to preparative isolation and spectral structure determination studies. The chloroform extract contained many components, and due to the small quantity of extract available, enough pure compound(s) cannot be obtained for structure determination studies, though the n-hexane extract afforded two known compounds, totarol (1) and taraxasterol (2). The structures of the compounds (1 and 2) were determined by H-1 and( 13)C NMR experiments. The pure compounds were also tested for their acetylcholinesterase inhibitory properties. For compound 1, the IC50 value was found to be 87.88 mu g/mL. However, no inhibition was seen for 2. Anthemis tricolor was established to be a valuable source of pharmacologically active compounds and requires further studies.en_US
dc.identifier.doi10.1002/cbdv.202300913
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue2en_US
dc.identifier.pmid38116908en_US
dc.identifier.scopus2-s2.0-85181669288en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202300913
dc.identifier.urihttps://hdl.handle.net/11454/104279
dc.identifier.volume21en_US
dc.identifier.wosWOS:001138860200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectAnthemis Tricoloren_US
dc.subjectTotarolen_US
dc.subjectTaraxasterolen_US
dc.subjectAcheen_US
dc.subjectCytotoxic Activityen_US
dc.titleAnthemis tricolor Containing Unusual Totarol with Cytotoxic and Acetylcholinesterase-Inhibitory Activityen_US
dc.typeArticleen_US

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