Altered level of apurinic/apyrimidinic endonuclease/redox factor-1 (APE/REF-1) mRNA in the hippocampus of ovariectomized rats treated by raloxifene against kainic acid

Basit Öğe Kaydı
dc.contributor.authorYalcin, A
dc.contributor.authorKanit, L
dc.contributor.authorDurmaz, G
dc.contributor.authorSargin, S
dc.contributor.authorTerek, CH
dc.contributor.authorTanyolac, B
dc.date.accessioned2019-10-27T19:23:55Z
dc.date.available2019-10-27T19:23:55Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstract1. Accumulated clinical evidence suggests that selective oestrogen receptor modulators (SERM), such as raloxifene, may be neuroprotective. Oxidative stress is a likely molecular mechanism in the neurotoxicity of kainic acid (KA), an excitotoxic substance. The expression levels of the apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) gene seem to correlate with cellular sensitivity to reactive oxygen species (ROS) and a reduction in the expression of APE/Ref-1 may cause oxidative DNA damage. 2. The aim of the present study was to assess the effects of KA and raloxifene on the level of APE/Ref-1 mRNA in the hippocampus of ovariectomized rats. The expression of the APE/Ref-1 gene was quantified using reverse transcription followed by real-time polymerase chain reaction. 3. The results show that the level of APE/Ref-1 mRNA increased significantly in raloxifene-treated rats. However, raloxifene treatment did not affect the seizure severity induced by KA. We also observed that raloxifene treatment against simultaneous KA injection maintained the increased level of APE/Ref-1 mRNA in the hippocampus. 4. Therefore, the results of the present study seem to support previous data suggesting the potential significance of raloxifene in neuroprotection.en_US
dc.identifier.doi10.1111/j.0305-1870.2005.04239.xen_US
dc.identifier.endpage614en_US
dc.identifier.issn0305-1870
dc.identifier.issue8en_US
dc.identifier.pmid16120186en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage611en_US
dc.identifier.urihttps://doi.org/10.1111/j.0305-1870.2005.04239.x
dc.identifier.urihttps://hdl.handle.net/11454/39230
dc.identifier.volume32en_US
dc.identifier.wosWOS:000230757700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAPE/ Ref-1en_US
dc.subjecthippocampusen_US
dc.subjectkainic aciden_US
dc.subjectovariectomyen_US
dc.subjectraloxifeneen_US
dc.subjectreal-time polymerase chain reactionen_US
dc.subjectselective oestrogen receptor modulatorsen_US
dc.titleAltered level of apurinic/apyrimidinic endonuclease/redox factor-1 (APE/REF-1) mRNA in the hippocampus of ovariectomized rats treated by raloxifene against kainic aciden_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu