Injectable platelet-rich fibrin as treatment for temporomandibular joint osteoarthritis: A randomized controlled clinical trial

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dc.authorscopusid8608137700
dc.authorscopusid57789589600
dc.authorscopusid24168992900
dc.authorscopusid6603287951
dc.authorscopusid7801650974
dc.contributor.authorIsik, Gozde
dc.contributor.authorKenc, Selin
dc.contributor.authorKoyuncu, Banu Ozveri
dc.contributor.authorGunbay, Sevtap
dc.contributor.authorGunbay, Tayfun
dc.date.accessioned2023-01-12T19:55:11Z
dc.date.available2023-01-12T19:55:11Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractThe purpose of this study was to assess the treatment outcomes of intraarticular injection of injectable platelet-rich fibrin (i-PRF) after arthrocentesis in patients with temporomandibular joint osteoarthritis (TMJ-OA). Patients were randomly assigned to one of two treatment groups: those who received intraarticular injection of i-PRF after arthrocentesis procedure -the i-PRF group; and those who un-derwent the arthrocentesis procedure alone -the control group. The primary outcome variable was pain, the level of which was measured preoperatively and at 1, 2, 3, 6, and 12 months postoperatively. The secondary outcome variables included maximum mouth opening (MMO), and lateral and protrusive movements. Of the total of 36 patients, 18 were analyzed in the i-PRF group and 18 in the control group. There were significant differences between the groups in terms of pain levels and measurements of MMO, lateral movement, and protrusive movement over the 12 months of follow-up (p < 0.001). Sig-nificant increases in pain levels and decreases in measurements of MMO, lateral movement, and pro-trusive movement were observed in the control group from the 6th to 12th month postoperatively (p < 0.001). In contrast, no significant differences were found in both pain levels and measurements of MMO, lateral, and protrusive movements for the i-PRF group from the 2nd to the 12th month post-operatively. Within the limitations of the study it seems that intraarticular injection of i-PRF after arthrocentesis should be preferred whenever appropriate because when reducing pain intensity and improving functional jaw movement is the priority. (c) 2022 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination Unit [22038]en_US
dc.description.sponsorshipThis study was supported by the Ege University Scientific Research Projects Coordination Unit (grant number: 22038) .en_US
dc.identifier.doi10.1016/j.jcms.2022.06.006
dc.identifier.endpage582en_US
dc.identifier.issn1010-5182
dc.identifier.issn1878-4119
dc.identifier.issue7en_US
dc.identifier.pmid35798596en_US
dc.identifier.scopus2-s2.0-85133679546en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage576en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcms.2022.06.006
dc.identifier.urihttps://hdl.handle.net/11454/76631
dc.identifier.volume50en_US
dc.identifier.wosWOS:000837280800007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTemporomandibular jointen_US
dc.subjectArthrocentesisen_US
dc.subjectInjectable platelet -rich fibrinen_US
dc.subjectIntraarticular injectionen_US
dc.subjectPain intensityen_US
dc.subjectFunctional jaw movementen_US
dc.subjectPlus Hyaluronic-Aciden_US
dc.subjectIntraarticular Injectionen_US
dc.subjectPlasma Injectionen_US
dc.subjectArthrocentesisen_US
dc.subjectDisordersen_US
dc.subjectSuperioren_US
dc.subjectReductionen_US
dc.subjectPlaceboen_US
dc.titleInjectable platelet-rich fibrin as treatment for temporomandibular joint osteoarthritis: A randomized controlled clinical trialen_US
dc.typeArticleen_US

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